Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.37 |
| ▸ | CA4 | P22748 | 2/20 | 0.37 |
| ▸ | IMPDH2 | P12268 | 2/20 | 0.37 |
| ▸ | ERN1 | O75460 | 2/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA6 | P23280 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14612683 | 0.84 | CA2 (0.41) | KMT2ACYP1A2CYP2D6MEN1SMN1; SMN2 | |
| SCHEMBL8427155 | 0.82 | KMT2A (0.54) | KMT2ACYP1A2CYP2D6MEN1SMN1; SMN2 | |
| SCHEMBL5272430 | 0.81 | ALDH1A1 (0.46) | KMT2ACYP1A2CYP2D6MEN1SMN1; SMN2 | |
| SCHEMBL4932262 | 0.79 | KMT2A (0.46) | KMT2ACYP1A2CYP2D6MEN1SMN1; SMN2 | |
| SCHEMBL21198098 | 0.77 | THRB (0.47) | KMT2ACYP1A2CYP2D6MEN1SMN1; SMN2 | |
| SCHEMBL30930936 | 0.77 | CA2 (0.52) | KMT2AMEN1SMN1; SMN2CA2CA4 | |
| SCHEMBL9952803 | 0.76 | TAAR1 (0.49) | KMT2ACYP1A2MEN1SMN1; SMN2CA2 | |
| SCHEMBL4021512 | 0.75 | ERN1 (0.55) | KMT2ACYP1A2MEN1CYP2C9CYP2C19 | |
| SCHEMBL2389960 | 0.75 | ERN1 (0.55) | CYP1A2CYP2C19CA2CA4ERN1 | |
| SCHEMBL10265435 | 0.75 | KMT2A (0.50) | KMT2ACYP1A2CYP2D6MEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655374-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | Incyte Corporation (US) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012087881-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2012-06-28 | — | — | WO | disclosed |