Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 1/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.49 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | RARB | P10826 | 2/20 | 0.44 |
| ▸ | RARA | P10276 | 1/20 | 0.43 |
| ▸ | RARG | P13631 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.41 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3649295 | 0.85 | HTR7 (0.54) | RXRAEPHX2NR1H4LMNAMAPK1 | |
| SCHEMBL7887028 | 0.85 | MRGPRX4 (0.49) | EPHX2NR1H4LMNAMAPK1HTT | |
| SCHEMBL7513592 | 0.85 | EPHX2 (0.51) | RXRAEPHX2NR1H4LMNAMAPK1 | |
| SCHEMBL13535960 | 0.84 | EPHX2 (0.51) | RXRAEPHX2NR1H4LMNAMAPK1 | |
| SCHEMBL27142279 | 0.84 | RXRA (0.48) | RXRAEPHX2NR1H4LMNAMAPK1 | |
| Hydrochloric Acid SCHEMBL3654867 | 0.84 | HTR7 (0.53) | RXRAEPHX2NR1H4LMNAMAPK1 | |
| SCHEMBL27885537 | 0.82 | TSHR (0.44) | MAPK1RARBRARARARGCA2 | |
| Hydrochloric Acid SCHEMBL30460794 | 0.82 | CA2 (0.43) | CA2HTR7HSD17B10CES2CES1 | |
| SCHEMBL4124943 | 0.81 | EPHX2 (0.55) | RXRAEPHX2NR1H4LMNAMAPK1 | |
| SCHEMBL24213979 | 0.81 | EPHX2 (0.49) | RXRAEPHX2NR1H4LMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012085935-A2 | COMPOUNDS AS INHIBITORS OF RENIN | CADILA HEALTHCARE LIMITED (IN) | 2012-06-28 | — | — | WO | disclosed |