Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 6/20 | 0.36 |
| ▸ | THRB | P10828 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.34 |
| ▸ | MAPK9 | P45984 | 5/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.32 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.32 |
| ▸ | RPS27 | P42677 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14742217 | 0.82 | CYP1A2 (0.34) | MAPK8THRBHTTPOLBALOX15 | |
| SCHEMBL14742479 | 0.80 | KDM4E (0.32) | THRBHTTPOLBALOX15CYP1A2 | |
| SCHEMBL9953766 | 0.80 | HTT (0.36) | MAPK8THRBHTTPOLBALOX15 | |
| SCHEMBL9954200 | 0.79 | HTR2A (0.36) | MAPK8THRBHTTPOLBALOX15 | |
| SCHEMBL9952820 | 0.76 | THRB (0.36) | MAPK8THRBHTTPOLBALOX15 | |
| SCHEMBL9951984 | 0.75 | PIK3CD (0.44) | MAPK8MAPK9MAPTKDM4EPRKD3 | |
| SCHEMBL9929200 | 0.74 | TSHR (0.39) | MAPK8THRBHTTPOLBALOX15 | |
| SCHEMBL28048048 | 0.72 | KDM4E (0.43) | THRBHTTPOLBALOX15CYP1A2 | |
| SCHEMBL9952473 | 0.72 | IMPDH2 (0.41) | POLBHSD17B10CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL14736127 | 0.70 | POLB (0.33) | MAPK8THRBHTTPOLBALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655374-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | Incyte Corporation (US) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012087881-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2012-06-28 | — | — | WO | disclosed |