Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.48 |
| ▸ | ALPL | P05186 | 1/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.44 |
| ▸ | KDR | P35968 | 4/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.39 |
| ▸ | ACLY | P53396 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9953720 | 0.86 | ALPL (0.62) | PIK3CAALPLPOLBPIK3CDPIK3C3 | |
| SCHEMBL9953341 | 0.84 | ALPL (0.51) | LMNAPIK3CAALPLPOLBPIK3CD | |
| SCHEMBL790655 | 0.81 | PIK3C3 (0.53) | PIK3CAPIK3C3MTOR | |
| SCHEMBL29556116 | 0.80 | PIK3CD (0.57) | PIK3CAALPLPIK3CDBRD4PIK3C3 | |
| SCHEMBL12276481 | 0.80 | PIK3CD (0.57) | PIK3CAALPLPIK3CDBRD4PIK3C3 | |
| SCHEMBL31029634 | 0.80 | BRD4 (0.47) | ALPLPIK3CDBRD4PIK3C3PIK3CB | |
| SCHEMBL454986 | 0.80 | LMNA (0.49) | LMNAPIK3CATSHRHSD17B10PIK3C3 | |
| SCHEMBL9953252 | 0.79 | PDGFRB (0.58) | PIK3CAALPLPDGFRBKDRPIK3CD | |
| SCHEMBL110313 | 0.78 | ALPL (0.55) | PIK3CAALPLPIK3CDMTORPIK3CB | |
| SCHEMBL29434933 | 0.78 | ALPL (0.55) | PIK3CAALPLPIK3CDMTORPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012174312-A2 | BENZIMIDAZOLE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-12-20 | — | — | WO | disclosed |
| WO-2012087938-A1 | QUINAZOLINONE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-06-28 | — | — | WO | disclosed |
| WO-2012087938-A1 | QUINAZOLINONE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-06-28 | — | — | WO | disclosed |