Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 2/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 7/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | F9 | P00740 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.35 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.34 |
| ▸ | GCGR | P47871 | 2/20 | 0.34 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.33 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18917317 | 0.85 | HIF1A (0.37) | HIF1APIK3CDP2RX7SLC2A1GCGR | |
| SCHEMBL9928955 | 0.78 | PIK3CD (0.47) | PIK3CD | |
| SCHEMBL9953631 | 0.78 | PIK3CD (0.38) | HIF1APIK3CDMAPTHTT | |
| SCHEMBL17138427 | 0.73 | PIK3CD (0.47) | PIK3CD | |
| SCHEMBL14742313 | 0.73 | PIK3CD (0.53) | PIK3CDGCGR | |
| SCHEMBL9952473 | 0.72 | IMPDH2 (0.41) | HIF1ASLC2A1IMPDH2 | |
| SCHEMBL14742450 | 0.71 | PDE10A (0.39) | PIK3CDMAPT | |
| SCHEMBL14742496 | 0.71 | PIK3CD (0.55) | PIK3CD | |
| SCHEMBL9952249 | 0.70 | HCRTR1 (0.38) | PIK3CDP2RX7SLC2A1 | |
| SCHEMBL9952754 | 0.69 | IMPDH2 (0.42) | HIF1ASLC2A1IMPDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655374-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | Incyte Corporation (US) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012087881-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2012-06-28 | — | — | WO | disclosed |