Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 7/20 | 0.33 |
| ▸ | FFAR4 | Q5NUL3 | 5/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.32 |
| ▸ | F10 | P00742 | 1/20 | 0.31 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.31 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.31 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.31 |
| ▸ | MGAT2 | Q10469 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9952898 | 0.90 | CYP11B1 (0.37) | L3MBTL1LMNAFFAR1FFAR4CYP11B1 | |
| SCHEMBL9928869 | 0.80 | L3MBTL1 (0.37) | L3MBTL1LMNAFFAR1FFAR4HSD17B10 | |
| SCHEMBL9928954 | 0.78 | MEN1 (0.36) | L3MBTL1LMNAHSD17B10CYP11B1CYP11B2 | |
| SCHEMBL9952988 | 0.78 | L3MBTL1 (0.37) | L3MBTL1LMNAFFAR1FFAR4HSD17B10 | |
| SCHEMBL9952993 | 0.78 | FFAR1 (0.36) | FFAR1FFAR4HSD17B10MAPK1 | |
| SCHEMBL9953061 | 0.70 | PIK3CD (0.39) | FFAR1FFAR4 | |
| SCHEMBL9929578 | 0.70 | CYP11B1 (0.37) | L3MBTL1LMNAFFAR1FFAR4HSD17B10 | |
| SCHEMBL9953131 | 0.70 | TAAR1 (0.31) | — | |
| SCHEMBL18927064 | 0.69 | CYP11B1 (0.39) | L3MBTL1LMNACYP11B1CYP11B2KMT2A | |
| SCHEMBL9929279 | 0.69 | TP53 (0.42) | L3MBTL1CYP11B1CYP11B2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655374-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | Incyte Corporation (US) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012087881-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2012-06-28 | — | — | WO | disclosed |