Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 18/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 16/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | GFER | P55789 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9953061 | 0.93 | PIK3CD (0.39) | FFAR1FFAR4 | |
| SCHEMBL9928879 | 0.82 | PIK3CD (0.42) | — | |
| SCHEMBL9951999 | 0.79 | RPS6KB1 (0.33) | HSD17B10 | |
| SCHEMBL9953145 | 0.78 | L3MBTL1 (0.34) | FFAR1FFAR4HSD17B10MAPK1 | |
| Trifluoroacetic Acid SCHEMBL9929228 | 0.78 | PIK3CD (0.39) | — | |
| SCHEMBL9953808 | 0.77 | PIK3CD (0.38) | ALDH1A1HSD17B10MAPTMAPK1 | |
| SCHEMBL9954211 | 0.75 | LMNA (0.39) | FFAR1KDM4EALDH1A1HSD17B10MAPK1 | |
| SCHEMBL9929197 | 0.75 | PIK3CD (0.52) | — | |
| SCHEMBL18935601 | 0.73 | PIK3CD (0.42) | — | |
| SCHEMBL9953815 | 0.72 | PIK3CD (0.35) | KDM4EALDH1A1HSD17B10MAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655374-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | Incyte Corporation (US) | 2013-10-30 | — | — | EP | claimed |
| WO-2012087881-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2012-06-28 | — | — | WO | claimed |
| EP-2655374-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | Incyte Corporation (US) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012087881-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2012-06-28 | — | — | WO | disclosed |