Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 6/20 | 0.35 |
| ▸ | FFAR4 | Q5NUL3 | 5/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 6/20 | 0.35 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.35 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.35 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9953145 | 0.90 | L3MBTL1 (0.34) | CYP11B1CYP11B2FFAR1FFAR4TP53 | |
| SCHEMBL9929578 | 0.81 | CYP11B1 (0.37) | CYP11B1CYP11B2FFAR1FFAR4TP53 | |
| SCHEMBL18927064 | 0.81 | CYP11B1 (0.39) | CYP11B1CYP11B2TP53NPC1ALDH1A1 | |
| SCHEMBL9929279 | 0.80 | TP53 (0.42) | CYP11B1CYP11B2TP53NPC1ALDH1A1 | |
| SCHEMBL9953061 | 0.79 | PIK3CD (0.39) | FFAR1FFAR4 | |
| SCHEMBL9952988 | 0.75 | L3MBTL1 (0.37) | FFAR1FFAR4TP53TAAR1LMNA | |
| SCHEMBL21986439 | 0.74 | CYP11B1 (0.37) | CYP11B1CYP11B2FFAR1TP53NPC1 | |
| SCHEMBL9953794 | 0.73 | TAAR1 (0.40) | FFAR1FFAR4TAAR1 | |
| SCHEMBL9953176 | 0.72 | LMNA (0.39) | TAAR1LMNAL3MBTL1 | |
| SCHEMBL9952729 | 0.71 | PIK3CD (0.44) | ALDH1A1PKMP2RX7TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655374-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | Incyte Corporation (US) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012087881-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2012-06-28 | — | — | WO | disclosed |