Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 13/20 | 0.36 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.34 |
| ▸ | PDCD1LG2 | Q9BQ51 | 1/20 | 0.34 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.32 |
| ▸ | CTSA | P10619 | 1/20 | 0.32 |
| ▸ | F10 | P00742 | 2/20 | 0.31 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.31 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9953244 | 0.89 | PIK3CD (0.37) | PIK3CDCTSAHCRTR1HCRTR2 | |
| SCHEMBL9952249 | 0.84 | HCRTR1 (0.38) | PIK3CDCTSAHCRTR1HCRTR2 | |
| SCHEMBL9929633 | 0.78 | PIK3CD (0.47) | PIK3CDCD274PDCD1LG2 | |
| Hydrochloric Acid SCHEMBL9929471 | 0.77 | PIK3CD (0.46) | PIK3CDCD274PDCD1LG2CTSA | |
| SCHEMBL9952247 | 0.74 | PIK3CD (0.46) | PIK3CDCTSA | |
| SCHEMBL9929037 | 0.71 | PIK3CD (0.41) | PIK3CDCTSA | |
| SCHEMBL9952278 | 0.71 | ALDH1A1 (0.38) | CD274PDCD1LG2 | |
| SCHEMBL9952356 | 0.69 | NQO2 (0.43) | — | |
| SCHEMBL9952282 | 0.69 | NQO2 (0.43) | — | |
| SCHEMBL28712872 | 0.69 | ALDH1A1 (0.44) | CD274PDCD1LG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655374-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | Incyte Corporation (US) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012087881-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2012-06-28 | — | — | WO | disclosed |