SCHEMBL995346

SCHEMBL995346

ClC(Cl)(OOC(Cl)(Cl)c1ccccc1)c1ccccc1

nearest known ligand 0.55

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
TSHR P16473 4/20 0.55
MAPK1 P28482 1/20 0.48
CYP1A2 P05177 1/20 0.44
KCNN4 O15554 5/20 0.41
ALDH1A1 P00352 2/20 0.41
ALOX15 P16050 1/20 0.39
KIF11 P52732 1/20 0.34
ORAI1 Q96D31 1/20 0.33
ORAI2 Q96SN7 1/20 0.33
ORAI3 Q9BRQ5 1/20 0.33
TRPV6 Q9H1D0 1/20 0.33
TAAR1 Q96RJ0 1/20 0.33
PTPN1 P18031 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL547587 0.82 TSHR (0.55) TSHRMAPK1CYP1A2KCNN4ALDH1A1
SCHEMBL28699621 0.79 TSHR (0.41) TSHRMAPK1CYP1A2KCNN4ALDH1A1
SCHEMBL10707751 0.78 TSHR (0.50) TSHRMAPK1CYP1A2KCNN4ALDH1A1
SCHEMBL7201481 0.78 TSHR (0.50) TSHRMAPK1CYP1A2KCNN4ALDH1A1
SCHEMBL28090932 0.78 ALDH1A1 (0.52) TSHRMAPK1CYP1A2KCNN4ALDH1A1
SCHEMBL1224334 0.78 TSHR (0.50) TSHRMAPK1CYP1A2KCNN4ALDH1A1
SCHEMBL9798410 0.76 TSHR (0.48) TSHRMAPK1CYP1A2KCNN4ALDH1A1
SCHEMBL29049150 0.72 TSHR (0.44) TSHRMAPK1CYP1A2KCNN4ALDH1A1
SCHEMBL2345811 0.72 CYP1A2 (0.52) TSHRMAPK1CYP1A2KCNN4ALDH1A1
SCHEMBL3988998 0.72 TSHR (0.44) TSHRMAPK1CYP1A2KCNN4ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4090714-A1 NON-POROUS MICROPARTICLES Covestro (Netherlands) B.V. (NL) 2022-11-23 EP disclosed
US-20110273093-A1 ENCAPSULATED COMPACT FLUORESCENT BULBS AND ARTICLES AND METHODS OF MANUFACTURE CALDWELL GREGORY 2011-11-10 US disclosed
WO-2011006089-A2 COATED GLASS BOTTLES, ENCAPSULATED COMPACT FLUORESCENT BULBS AND ARTICLES AND METHODS OF MANUFACTURE GREG CALDWELL COMPANY, LLC (US) 2011-01-13 WO disclosed
EP-1419205-B1 LOW GLOSS FREE RADICAL POWDER COATINGS DU PONT (US) 2007-01-10 EP disclosed
US-20060241248-A1 Glazing joint EYE-BOND LIMITED (GB) 2006-10-26 US disclosed
EP-1565537-A1 GLAZING JOINT Foreman, Paul David (GB) 2005-08-24 EP disclosed
WO-2004039908-A1 GLAZING JOINT FOREMAN PAUL DAVID (GB) 2004-05-13 WO disclosed
US-6447916-B1 FLUOROPOLYMER DIRECTLY BONDED TO A SILICONE-CONTAINING POLYMER; FLUOROPOLYMER CAN PROVIDE A REACTIVE SITE THROUGH DEHYDROFLUORINATION OR BY INCORPORATING A REACTIVE MONOMER; PEROXIDE CURING/BONDING AGENT DYNEON, LLC 2002-09-10 US disclosed
EP-1112179-A1 MULTILAYER COMPOSITES DYNEON LLC (US) 2001-07-04 EP disclosed
JP-2000283369-A POLYOLEFIN JOINT OSAKA GAS CO LTD 2000-10-13 JP disclosed
US-4981885-A PAINTS HOECHST AG (DE) 1991-01-01 US disclosed
US-4965660-A HIGH RELIABILITY, STABILITY, SHOCKPROOF HITACHI, LTD. (JP) 1990-10-23 US disclosed
US-4841331-A SUBSTRATE COATED WITH COPOLYMER OF FLUOROOLEFIN AND UNSATURATED SILICON COMPOUND; STABILITY RICOH COMPANY, LTD. (JP) 1989-06-20 US disclosed
EP-0137385-B1 INTEGRATED CIRCUIT PACKAGE (1111111) HITACHI, LTD. (JP) 1988-03-02 EP disclosed
EP-0137385-A1 Integrated circuit package (1111111) HITACHI, LTD. (JP) 1985-04-17 EP disclosed
US-4425472-A WATER IN OIL EMULSIONS LORD CORPORATION (US) 1984-01-10 US disclosed
US-4205154-A Triallyl carbonate polymers PPG INDUSTRIES, INC. (US) 1980-05-27 US disclosed
US-4144262-A ALLYL POLYMERS FOR OPTICAL USES PPG INDUSTRIES, INC. (US) 1979-03-13 US disclosed
US-4043982-A ADHESIVES, SEALANTS, POTTING COMPOUNDS LOCTITE (IRELAND) LIMITED (EI) 1977-08-23 US disclosed
US-3991752-A PENILE IMPLANT DOW CORNING CORPORATION (US) 1976-11-16 US disclosed