Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | IMPDH2 | P12268 | 6/20 | 0.43 |
| ▸ | GRIN2D | O15399 | 4/20 | 0.40 |
| ▸ | GRIN3B | O60391 | 4/20 | 0.40 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.40 |
| ▸ | GRIN2A | Q12879 | 4/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.40 |
| ▸ | GRIN2C | Q14957 | 4/20 | 0.40 |
| ▸ | GRIN3A | Q8TCU5 | 4/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2013694 | 0.81 | GRIN2D (0.40) | TSHRALDH1A1IMPDH2GRIN2DGRIN3B | |
| SCHEMBL6882078 | 0.80 | HPD (0.39) | ALDH1A1KDM4EMAPTDCTPP1SMN1; SMN2 | |
| SCHEMBL9952629 | 0.76 | IMPDH2 (0.47) | TSHRALDH1A1IMPDH2KDM4ESMN1; SMN2 | |
| SCHEMBL9952076 | 0.76 | IMPDH2 (0.47) | ALDH1A1IMPDH2GRIN2DGRIN3BGRIN1 | |
| SCHEMBL9953161 | 0.76 | IMPDH2 (0.47) | ALDH1A1IMPDH2KDM4E | |
| SCHEMBL2012585 | 0.75 | GRIN2D (0.36) | TSHRALDH1A1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL3244211 | 0.74 | ALDH1A1 (0.41) | TSHRALDH1A1TDP1IMPDH2GRIN2D | |
| SCHEMBL14742448 | 0.74 | IMPDH2 (0.45) | ALDH1A1TDP1IMPDH2KDM4EMAPT | |
| SCHEMBL9928962 | 0.72 | TSHR (0.44) | TSHRALDH1A1TDP1IMPDH2GRIN2D | |
| SCHEMBL5998652 | 0.72 | GRIN2D (0.52) | TSHRALDH1A1TDP1GRIN2DGRIN3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655374-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | Incyte Corporation (US) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012087881-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2012-06-28 | — | — | WO | disclosed |