Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.74 |
| ▸ | RAB9A | P51151 | 1/20 | 0.74 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.69 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.69 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.69 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.69 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.69 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.69 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.69 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.69 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.69 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.69 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.69 |
| ▸ | HTR7 | P34969 | 1/20 | 0.65 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.54 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3866967 | 0.98 | NPC1 (0.77) | NPC1RAB9AHDAC3HDAC4HDAC1 | |
| SCHEMBL296337 | 0.94 | NPC1 (0.84) | NPC1RAB9AHDAC3HDAC4HDAC1 | |
| SCHEMBL1040636 | 0.92 | NPC1 (0.87) | NPC1RAB9AHDAC3HDAC4HDAC1 | |
| SCHEMBL3424496 | 0.92 | NPC1 (0.87) | NPC1RAB9AHDAC3HDAC4HDAC1 | |
| SCHEMBL9680984 | 0.92 | NPC1 (0.87) | NPC1RAB9AHDAC3HDAC4HDAC1 | |
| SCHEMBL9680520 | 0.90 | NPC1 (0.91) | NPC1RAB9AHTR7L3MBTL1LMNA | |
| SCHEMBL315309 | 0.86 | RAB9A (0.69) | NPC1RAB9AHTR7L3MBTL1LMNA | |
| SCHEMBL5253936 | 0.85 | NPC1 (0.74) | NPC1RAB9AHDAC3HDAC4HDAC1 | |
| SCHEMBL7392018 | 0.85 | NPC1 (0.74) | NPC1RAB9AHDAC1HDAC8HTR7 | |
| SCHEMBL5253938 | 0.85 | NPC1 (0.74) | NPC1RAB9AHDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2661265-B1 | QUINOLINES AND AZA-QUINOLINES AS CRTH2 RECEPTOR MODULATORS | MERCK SHARP & DOHME (US) | 2017-03-08 | — | — | EP | disclosed |
| US-9290453-B2 | Quinolines and aza-quinolines as CRTH2 receptor modulators | MERCK SHARP & DOHME CORP. (US) | 2016-03-22 | — | — | US | disclosed |
| EP-2661265-A1 | QUINOLINES AND AZA-QUINOLINES AS CRTH2 RECEPTOR MODULATORS | Merck Sharp & Dohme Corp. (US) | 2013-11-13 | — | — | EP | disclosed |
| US-20130296300-A1 | QUINOLINES AND AZA-QUINOLINES AS CRTH2 RECEPTOR MODULATORS | MERCK SHARP & DOHME LLC | 2013-11-07 | — | — | US | disclosed |
| WO-2012087872-A1 | QUINOLINES AND AZA-QUINOLINES AS CRTH2 RECEPTOR MODULATORS | MERCK SHARP & DOHME CORP. (US) | 2012-06-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130296300-A1 | QUINOLINES AND AZA-QUINOLINES AS CRTH2 RECEPTOR MODULATORS | HRH2, NPY2R, CNKSR1 | NPC1 2212/4885RAB9A 563/4885HDAC3 845/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.