Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 5/20 | 0.43 |
| ▸ | CA1 | P00915 | 5/20 | 0.43 |
| ▸ | CA2 | P00918 | 5/20 | 0.43 |
| ▸ | CA9 | Q16790 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HPD | P32754 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9954526 | 0.86 | POLB (0.54) | POLBMAPTATMCA12CA1 | |
| SCHEMBL10517573 | 0.81 | NPC1 (0.46) | POLBALDH1A1SMN1; SMN2ESR2MEN1 | |
| SCHEMBL9954457 | 0.80 | HCAR1 (0.50) | CA12CA1CA2CA9SMN1; SMN2 | |
| SCHEMBL9954122 | 0.79 | ESR2 (0.44) | POLBMAPTATMCA12CA1 | |
| SCHEMBL2120797 | 0.79 | POLB (0.53) | POLBMAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL2119910 | 0.79 | ALDH1A1 (0.62) | POLBMAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL12468498 | 0.77 | POLB (0.51) | POLBMAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL9955556 | 0.77 | CA12 (0.47) | POLBCA12CA1CA2CA9 | |
| SCHEMBL9953965 | 0.77 | POLB (0.41) | POLBCA12CA1CA2CA9 | |
| SCHEMBL9954100 | 0.77 | SMN1; SMN2 (0.55) | POLBMAPTALDH1A1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012087938-A1 | QUINAZOLINONE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-06-28 | — | — | WO | disclosed |
| WO-2012087938-A1 | QUINAZOLINONE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-06-28 | — | — | WO | disclosed |