Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL789757 | 0.88 | GAA (0.58) | TSHRKDM4ELMNAALDH1A1NPSR1 | |
| SCHEMBL14305917 | 0.86 | GAA (0.57) | TSHRKDM4ELMNAALDH1A1NPSR1 | |
| SCHEMBL10289141 | 0.85 | MAPT (0.49) | TSHRKDM4ELMNAALDH1A1GAA | |
| SCHEMBL28096087 | 0.82 | HSD17B10 (0.52) | TSHRKDM4ELMNAALDH1A1KMT2A | |
| SCHEMBL730137 | 0.80 | KDM4E (0.58) | KDM4EKMT2ANPC1HSD17B10MEN1 | |
| SCHEMBL9954366 | 0.78 | ALPL (0.50) | TSHRHTTKDM4ELMNAALDH1A1 | |
| SCHEMBL9955070 | 0.78 | GAA (0.41) | TSHRKDM4EALDH1A1NPSR1KMT2A | |
| SCHEMBL9954790 | 0.77 | SHMT2 (0.41) | TSHRHTTKDM4ELMNAALDH1A1 | |
| SCHEMBL15052436 | 0.76 | GAA (0.77) | TSHRKDM4ELMNAALDH1A1NPSR1 | |
| SCHEMBL9953196 | 0.73 | PIK3CG (0.46) | HTTKDM4EKMT2AHSD17B10CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012174312-A2 | BENZIMIDAZOLE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-12-20 | — | — | WO | disclosed |
| WO-2012087938-A1 | QUINAZOLINONE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-06-28 | — | — | WO | disclosed |