Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 3/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.34 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9929552 | 0.83 | PIK3CD (0.41) | — | |
| Trifluoroacetic Acid SCHEMBL9954032 | 0.81 | PTGDR (0.32) | — | |
| SCHEMBL9960866 | 0.72 | LMNA (0.36) | — | |
| SCHEMBL2051000 | 0.67 | PIK3CD (0.33) | ADORA2AADORA2BTMIGD3ADORA1 | |
| SCHEMBL9960521 | 0.66 | — | — | |
| SCHEMBL9928703 | 0.64 | PIK3CD (0.49) | — | |
| SCHEMBL2052497 | 0.64 | TMIGD3 (0.33) | ADORA2AADORA2BTMIGD3ADORA1 | |
| Trifluoroacetic Acid SCHEMBL9953198 | 0.64 | PIK3CD (0.38) | — | |
| Trifluoroacetic Acid SCHEMBL9929550 | 0.64 | PIK3CD (0.45) | — | |
| SCHEMBL9952889 | 0.64 | CYP1A2 (0.45) | ADORA2AADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655374-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | Incyte Corporation (US) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012087881-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2012-06-28 | — | — | WO | disclosed |