Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 12/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.60 |
| ▸ | NPC1 | O15118 | 3/20 | 0.60 |
| ▸ | RAB9A | P51151 | 3/20 | 0.60 |
| ▸ | STAT1 | P42224 | 1/20 | 0.60 |
| ▸ | MAOB | P27338 | 7/20 | 0.60 |
| ▸ | MAOA | P21397 | 4/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.56 |
| ▸ | HPGD | P15428 | 3/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | CASP1 | P29466 | 1/20 | 0.53 |
| ▸ | CASP7 | P55210 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9956150 | 0.84 | GRM5 (1.00) | GRM5KDM4ENPC1RAB9ASTAT1 | |
| SCHEMBL10025794 | 0.75 | RAB9A (1.00) | GRM5KDM4ENPC1RAB9ASTAT1 | |
| SCHEMBL23656973 | 0.75 | GRM5 (0.95) | GRM5KDM4ENPC1RAB9ASTAT1 | |
| SCHEMBL9955104 | 0.75 | GRM5 (1.00) | GRM5NPC1RAB9AMAOBMAOA | |
| SCHEMBL9955400 | 0.75 | GRM5 (1.00) | GRM5KDM4ENPC1RAB9AMAOB | |
| SCHEMBL9955316 | 0.73 | GRM5 (1.00) | GRM5KDM4ENPC1RAB9ASTAT1 | |
| SCHEMBL9955087 | 0.72 | GRM5 (0.80) | GRM5KDM4ENPC1RAB9ASTAT1 | |
| SCHEMBL10025793 | 0.72 | GRM5 (0.80) | GRM5KDM4ENPC1RAB9ASTAT1 | |
| SCHEMBL10025784 | 0.72 | RAB9A (1.00) | GRM5KDM4ENPC1RAB9ASTAT1 | |
| SCHEMBL9956161 | 0.71 | GRM5 (1.00) | GRM5KDM4ENPC1RAB9ASTAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012085166-A1 | METABOTROPIC GLUTAMATE RECEPTOR MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2012-06-28 | — | — | WO | disclosed |