Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 7/20 | 1.00 |
| ▸ | MAOA | P21397 | 3/20 | 1.00 |
| ▸ | MAOB | P27338 | 3/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.80 |
| ▸ | NPC1 | O15118 | 2/20 | 0.80 |
| ▸ | RAB9A | P51151 | 2/20 | 0.80 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.80 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.80 |
| ▸ | CA1 | P00915 | 1/20 | 0.71 |
| ▸ | CA2 | P00918 | 1/20 | 0.71 |
| ▸ | CA4 | P22748 | 1/20 | 0.71 |
| ▸ | CA9 | Q16790 | 1/20 | 0.71 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10025790 | 0.88 | ALDH1A1 (0.80) | GRM5MAOAMAOBALDH1A1NPC1 | |
| SCHEMBL10025785 | 0.87 | MAOA (1.00) | GRM5MAOAMAOBALDH1A1NPC1 | |
| SCHEMBL9955038 | 0.84 | GRM5 (1.00) | GRM5MAOAMAOBALDH1A1NPC1 | |
| SCHEMBL9957176 | 0.82 | MAOA (0.80) | GRM5MAOAMAOBALDH1A1NPC1 | |
| SCHEMBL9955952 | 0.80 | MAOA (0.76) | GRM5MAOAMAOBALDH1A1NPC1 | |
| SCHEMBL23656973 | 0.78 | GRM5 (0.95) | GRM5MAOAMAOBNPC1RAB9A | |
| SCHEMBL9955104 | 0.78 | GRM5 (1.00) | GRM5MAOAMAOBALDH1A1NPC1 | |
| SCHEMBL9956150 | 0.78 | GRM5 (1.00) | GRM5MAOAMAOBALDH1A1NPC1 | |
| SCHEMBL15840839 | 0.75 | ALDH1A1 (0.62) | GRM5MAOAMAOBALDH1A1NPC1 | |
| SCHEMBL9954129 | 0.75 | GRM5 (1.00) | GRM5MAOAMAOBALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012085166-A1 | METABOTROPIC GLUTAMATE RECEPTOR MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2012-06-28 | — | — | WO | disclosed |