Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 2/20 | 0.58 |
| ▸ | GRM5 | P41594 | 2/20 | 0.58 |
| ▸ | SYK | P43405 | 2/20 | 0.54 |
| ▸ | CDK5 | Q00535 | 6/20 | 0.48 |
| ▸ | CDK5R1 | Q15078 | 6/20 | 0.48 |
| ▸ | CDK2 | P24941 | 6/20 | 0.48 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.48 |
| ▸ | CDK1 | P06493 | 2/20 | 0.48 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.48 |
| ▸ | CDC7 | O00311 | 1/20 | 0.48 |
| ▸ | IGF1R | P08069 | 1/20 | 0.46 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.45 |
| ▸ | CDK4 | P11802 | 2/20 | 0.44 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.44 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.44 |
| ▸ | CCND3 | P30281 | 1/20 | 0.44 |
| ▸ | FLT3 | P36888 | 1/20 | 0.44 |
| ▸ | CDK9 | P50750 | 1/20 | 0.44 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.44 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9958931 | 0.83 | GRM5 (0.55) | MAOBGRM5CDK5CDK5R1CDK2 | |
| SCHEMBL9958935 | 0.83 | GRM5 (0.70) | MAOBGRM5SYKCDK5CDK5R1 | |
| SCHEMBL9959907 | 0.83 | CDK5 (0.70) | MAOBGRM5CDK5CDK5R1CDK2 | |
| SCHEMBL17620607 | 0.82 | CDK5 (0.65) | MAOBGRM5CDK5CDK5R1CDK2 | |
| SCHEMBL19475557 | 0.81 | GRM5 (0.56) | MAOBGRM5SYKCDK5CDK5R1 | |
| SCHEMBL9959330 | 0.81 | CDK5 (0.71) | MAOBGRM5SYKCDK5CDK5R1 | |
| SCHEMBL30099826 | 0.77 | GRM5 (0.53) | MAOBGRM5SYKCDK5CDK5R1 | |
| SCHEMBL9955805 | 0.76 | PDGFRB (0.56) | MAOBGRM5SYKJAK3EGFR | |
| SCHEMBL22999621 | 0.75 | CDK5 (0.51) | CDK5CDK5R1CDK2CCNA2CDK1 | |
| SCHEMBL9959904 | 0.75 | CDK2 (0.67) | MAOBGRM5CDK5CDK5R1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012085167-A1 | METABOTROPIC GLUTAMATE RECEPTOR MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2012-06-28 | — | — | WO | disclosed |