Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK5 | Q00535 | 4/20 | 0.71 |
| ▸ | CDK5R1 | Q15078 | 4/20 | 0.71 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.71 |
| ▸ | CDK2 | P24941 | 2/20 | 0.71 |
| ▸ | AXL | P30530 | 4/20 | 0.57 |
| ▸ | TYRO3 | Q06418 | 4/20 | 0.57 |
| ▸ | MERTK | Q12866 | 4/20 | 0.57 |
| ▸ | KDR | P35968 | 3/20 | 0.53 |
| ▸ | SYK | P43405 | 1/20 | 0.53 |
| ▸ | CDK1 | P06493 | 1/20 | 0.50 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.50 |
| ▸ | EGFR | P00533 | 1/20 | 0.50 |
| ▸ | BRD4 | O60885 | 2/20 | 0.48 |
| ▸ | PLK1 | P53350 | 1/20 | 0.48 |
| ▸ | HTR2C | P28335 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23020822 | 0.90 | CDK5 (0.69) | CDK5CDK5R1CCNA2CDK2AXL | |
| Hydrochloric Acid SCHEMBL22999667 | 0.88 | CDK5 (0.67) | CDK5CDK5R1CCNA2CDK2AXL | |
| SCHEMBL9959676 | 0.88 | LMNA (0.54) | CDK5CDK5R1CCNA2CDK2AXL | |
| SCHEMBL9959983 | 0.86 | CDK5 (0.69) | CDK5CDK5R1CCNA2CDK2KDR | |
| SCHEMBL9959907 | 0.85 | CDK5 (0.70) | CDK5CDK5R1CCNA2CDK2AXL | |
| SCHEMBL9958935 | 0.82 | GRM5 (0.70) | CDK5CDK5R1CCNA2CDK2AXL | |
| SCHEMBL9958931 | 0.82 | GRM5 (0.55) | CDK5CDK5R1CCNA2CDK2AXL | |
| SCHEMBL17620607 | 0.81 | CDK5 (0.65) | CDK5CDK5R1CCNA2CDK2AXL | |
| SCHEMBL9959736 | 0.81 | MAPT (0.55) | CDK5CDK5R1CCNA2CDK2 | |
| SCHEMBL9954342 | 0.81 | MAOB (0.58) | CDK5CDK5R1CCNA2CDK2SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012085167-A1 | METABOTROPIC GLUTAMATE RECEPTOR MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2012-06-28 | — | — | WO | claimed |
| WO-2012085167-A1 | METABOTROPIC GLUTAMATE RECEPTOR MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2012-06-28 | — | — | WO | disclosed |