Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 15/20 | 0.36 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.36 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30036787 | 0.86 | CNR2 (0.35) | CNR2HSD17B10OPRK1CSNK2A1HIPK2 | |
| SCHEMBL316314 | 0.83 | HSD17B10 (0.50) | CNR2HSD17B10OPRK1 | |
| SCHEMBL14764185 | 0.83 | HTT (0.44) | CNR2HSD17B10OPRK1NPC1RAB9A | |
| Lithium SCHEMBL9954426 | 0.81 | HSD17B10 (0.49) | CNR2HSD17B10OPRK1 | |
| SCHEMBL11875941 | 0.81 | CNR2 (0.38) | CNR2HSD17B10OPRK1NPC1RAB9A | |
| SCHEMBL9954416 | 0.81 | HSD17B10 (0.49) | CNR2HSD17B10OPRK1 | |
| SCHEMBL8125788 | 0.81 | NNMT (0.46) | CNR2HSD17B10OPRK1 | |
| SCHEMBL29457453 | 0.81 | OPRK1 (0.49) | HSD17B10OPRK1 | |
| SCHEMBL757419 | 0.81 | OPRK1 (0.49) | HSD17B10OPRK1 | |
| SCHEMBL2628512 | 0.80 | CNR2 (0.37) | CNR2HSD17B10OPRK1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012087938-A1 | QUINAZOLINONE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-06-28 | — | — | WO | disclosed |