Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | TACR1 | P25103 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | GJB2 | P29033 | 1/20 | 0.45 |
| ▸ | TACR2 | P21452 | 1/20 | 0.45 |
| ▸ | NT5E | P21589 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 5/20 | 0.42 |
| ▸ | CDC25B | P30305 | 5/20 | 0.42 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.42 |
| ▸ | PTPN6 | P29350 | 2/20 | 0.42 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.42 |
| ▸ | TGM2 | P21980 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9954862 | 0.94 | LMNA (0.47) | LMNASMN1; SMN2TACR1HTTGJB2 | |
| SCHEMBL9954434 | 0.92 | TACR1 (0.53) | LMNASMN1; SMN2TACR1HTTNT5E | |
| SCHEMBL14413410 | 0.89 | TACR1 (0.51) | LMNASMN1; SMN2TACR1HTTTACR2 | |
| SCHEMBL9284116 | 0.86 | LMNA (0.56) | LMNASMN1; SMN2TACR1HTTGJB2 | |
| SCHEMBL8518190 | 0.86 | LMNA (0.56) | LMNASMN1; SMN2TACR1HTTGJB2 | |
| SCHEMBL8741356 | 0.84 | LMNA (0.58) | LMNASMN1; SMN2TACR1TACR2NT5E | |
| SCHEMBL9943628 | 0.82 | KMT2A (0.48) | TACR1TACR2NT5EPTPN1CDC25B | |
| SCHEMBL8586688 | 0.82 | LMNA (0.51) | LMNASMN1; SMN2TACR1TACR2NT5E | |
| SCHEMBL14413415 | 0.81 | TACR1 (0.52) | TACR1NT5EPTPN1CDC25BPTPN2 | |
| SCHEMBL6809787 | 0.81 | GJB2 (0.58) | GJB2TACR2NT5EPTPN1CDC25B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655389-A2 | COMPOUNDS | Novartis AG (CH) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012085668-A2 | COMPOUNDS | NOVARTIS AG (CH) | 2012-06-28 | — | — | WO | disclosed |