Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 5/20 | 0.51 |
| ▸ | NPC1 | O15118 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | CASP3 | P42574 | 1/20 | 0.51 |
| ▸ | GFER | P55789 | 1/20 | 0.51 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.51 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.51 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | HSD17B1 | P14061 | 3/20 | 0.51 |
| ▸ | HSD17B2 | P37059 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.49 |
| ▸ | BACE1 | P56817 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3459364 | 0.82 | HSD17B1 (0.54) | ALDH1A1MEN1KMT2ARAB9ANPC1 | |
| SCHEMBL12601168 | 0.82 | MAP4K4 (0.53) | ALDH1A1MEN1KMT2ARAB9ANPC1 | |
| SCHEMBL3500308 | 0.82 | CSNK2A1 (0.59) | ALDH1A1RAB9ANPC1MAPTPOLB | |
| SCHEMBL69900 | 0.81 | CSNK2A1 (0.62) | ALDH1A1RAB9ANPC1MAPTSMN1; SMN2 | |
| Bromide SCHEMBL22834317 | 0.80 | CSNK2A1 (0.61) | ALDH1A1RAB9ANPC1MAPTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL11145599 | 0.80 | CSNK2A1 (0.61) | ALDH1A1RAB9ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL2406426 | 0.79 | CSNK2A1 (0.49) | ALDH1A1RAB9ANPC1MAPTPOLB | |
| SCHEMBL9954919 | 0.79 | HSD17B1 (0.51) | ALDH1A1MEN1KMT2ARAB9ANPC1 | |
| SCHEMBL29389381 | 0.79 | CSNK2A1 (0.49) | ALDH1A1RAB9ANPC1MAPTPOLB | |
| SCHEMBL2406300 | 0.79 | KDM4E (0.54) | ALDH1A1MEN1KMT2ARAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3741757-B1 | DIHYDROINDOLIZINONE DERIVATIVE | DAIICHI SANKYO CO LTD (JP) | 2023-07-26 | — | — | EP | disclosed |
| CN-111630052-B | Dihydroindazinone derivatives | 第一三共株式会社 | 2023-04-18 | — | — | CN | disclosed |
| US-11530211-B2 | Dihydroindolizinone derivative | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2022-12-20 | — | — | US | disclosed |
| US-20220339260-A1 | METHOD FOR PRODUCING INSULIN-PRODUCING CELL USING DIHYDROINDOLIZINONE DERIVATIVES | TOKYO INSTITUTE OF TECHNOLOGY (JP) | 2022-10-27 | — | — | US | disclosed |
| EP-3998107-A1 | METHOD FOR PRODUCING INSULIN-PRODUCING CELL USING DIHYDROINDOLIZINONE DERIVATIVES | Tokyo Institute of Technology (JP) | 2022-05-18 | — | — | EP | disclosed |
| CN-114040966-A | Method for producing insulin-producing cell using dihydroindolizinone derivative | 国立大学法人东京工业大学 | 2022-02-11 | — | — | CN | disclosed |
| US-20210053965-A1 | DIHYDROINDOLIZINONE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2021-02-25 | — | — | US | disclosed |
| EP-3741757-A1 | DIHYDROINDOLIZINONE DERIVATIVE | Daiichi Sankyo Company, Limited (JP) | 2020-11-25 | — | — | EP | disclosed |
| CN-111630052-A | Dihydroindazinone derivatives | 第一三共株式会社 | 2020-09-04 | — | — | CN | disclosed |
| WO-2019142883-A1 | DIHYDROINDOLIZINONE DERIVATIVE | 第一三共株式会社 | 2019-07-25 | — | — | WO | disclosed |
| WO-2012085852-A1 | 3,8-DIAZA-BICYCLO[4.2.0]OCT-8-YL AMIDES | ACTELION PHARMACEUTICALS LTD (CH) | 2012-06-28 | — | — | WO | disclosed |
| WO-2012085857-A1 | 3,8-DIAZA-BICYCLO[4.2.0]OCT-3-YL AMIDES | ACTELION PHARMACEUTICALS LTD (CH) | 2012-06-28 | — | — | WO | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11530211-B2 | Dihydroindolizinone derivative | INSR, GPR119, IAPP | ALDH1A1 55/4885MEN1 1938/4885KMT2A 2004/4885 |
| US-20220339260-A1 | METHOD FOR PRODUCING INSULIN-PRODUCING CELL USING DIHYDROINDOLIZINONE DERIVATIVES | IAPP, INSR, GPR119 | ALDH1A1 422/4885MEN1 2467/4885KMT2A 2395/4885 |
| US-20210053965-A1 | DIHYDROINDOLIZINONE DERIVATIVE | INSR, GPR119, IAPP | ALDH1A1 55/4885MEN1 1938/4885KMT2A 2004/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.