Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 4/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.35 |
| ▸ | MKNK1 | Q9BUB5 | 4/20 | 0.35 |
| ▸ | MKNK2 | Q9HBH9 | 4/20 | 0.35 |
| ▸ | F7 | P08709 | 1/20 | 0.35 |
| ▸ | F3 | P13726 | 1/20 | 0.35 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.35 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.35 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.35 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.35 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.35 |
| ▸ | SIRT4 | Q9Y6E7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9953508 | 0.77 | TDP1 (0.58) | SIRT3TDP1KDM4EHTTCA12 | |
| SCHEMBL28975269 | 0.77 | SIRT3 (0.53) | SIRT3TDP1KDM4EHTTCA12 | |
| SCHEMBL366127 | 0.77 | TSHR (0.42) | KDM4ECA1CA2CA9GCK | |
| SCHEMBL25302808 | 0.71 | TP53 (0.46) | KDM4EHTTCA12CA1CA2 | |
| SCHEMBL4599652 | 0.71 | TP53 (0.42) | KDM4ECA12CA1CA2CA9 | |
| SCHEMBL14705645 | 0.70 | LOXL2 (0.40) | NAMPTCOMTPTGS1PTGS2 | |
| SCHEMBL25304013 | 0.70 | TP53 (0.48) | KDM4EHTTCA12CA1CA2 | |
| SCHEMBL1687197 | 0.69 | TDP1 (0.67) | SIRT3TDP1KDM4EHTTMKNK1 | |
| SCHEMBL1330970 | 0.69 | TDP1 (0.67) | SIRT3TDP1KDM4EHTTMKNK1 | |
| SCHEMBL16759706 | 0.69 | KIF18A (0.40) | KDM4EHTTGCKALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012087938-A1 | QUINAZOLINONE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-06-28 | — | — | WO | disclosed |