Sugi Predict

Sugi Predict / Compounds / SCHEMBL9955746

SCHEMBL9955746

SCHEMBL9955746

Cc1ccc(-c2nc3ccc(N4CCC(O)CC4)nn3c2C)cc1NC(=O)C(C)(C)C

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PTGER4 P35408 2/20 0.40
▸ FGFR1 P11362 1/20 0.40
▸ TP53 P04637 2/20 0.37
▸ ADORA2A P29274 1/20 0.36
▸ ADORA1 P30542 1/20 0.36
▸ CKS1B P61024 7/20 0.35
▸ SKP1 P63208 7/20 0.35
▸ SKP2 Q13309 7/20 0.35
▸ MAPT P10636 2/20 0.34
▸ POLB P06746 1/20 0.34
▸ KDM4E B2RXH2 2/20 0.33
▸ NPC1 O15118 2/20 0.33
▸ RAB9A P51151 2/20 0.33
▸ SMN1; SMN2 Q16637 2/20 0.33
▸ HASPIN Q8TF76 1/20 0.33
▸ GAA P10253 1/20 0.33
▸ ALOX15 P16050 1/20 0.33
▸ CASP1 P29466 1/20 0.33
▸ HTT P42858 1/20 0.33
▸ CASP7 P55210 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9956159 0.87 SYK (0.41) —
SCHEMBL9956948 0.83 PTGER4 (0.40) PTGER4FGFR1TP53ADORA2AADORA1
SCHEMBL9956260 0.80 TP53 (0.42) TP53ADORA1MAPTPOLBKDM4E
SCHEMBL9955783 0.79 RIPK1 (0.38) PTGER4FGFR1TP53MAPTKDM4E
SCHEMBL17328342 0.79 RIPK1 (0.38) PTGER4FGFR1TP53MAPTKDM4E
SCHEMBL9955779 0.79 RIPK1 (0.38) PTGER4FGFR1TP53MAPTKDM4E
SCHEMBL9955290 0.78 TP53 (0.41) TP53ADORA1MAPTPOLBKDM4E
SCHEMBL9956518 0.75 MAPT (0.39) MAPTKDM4ENPC1RAB9ASMN1; SMN2
SCHEMBL9956510 0.74 MAPT (0.37) TP53MAPTKDM4ENPC1RAB9A
SCHEMBL9957003 0.74 CSNK1D (0.42) TP53ADORA2AADORA1MAPTPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2635578-A1 2-ARYLIMIDAZO[1,2-B]PYRIDAZINE, 2-PHENYLIMIDAZO[1,2-A]PYRIDINE, AND 2-PHENYLIMIDAZO[1,2-A]PYRAZINE DERIVATIVES Hengrui (USA) Ltd. (US) 2013-09-11 — — EP claimed
US-20120178751-A1 2-ARYLIMIDAZO[1,2-B]PYRIDAZINE, 2-PHENYLIMIDAZO[1,2-A]PYRIDINE, AND 2-PHENYLIMIDAZO[1,2-A]PYRAZINE DERIVATIVES HENGRUI (USA), LTD. 2012-07-12 — — US claimed
WO-2012088411-A1 2-ARYLIMIDAZO[1,2-B]PYRIDAZINE, 2-PHENYLIMIDAZO[1,2-A]PYRIDINE, AND 2-PHENYLIMIDAZO[1,2-A]PYRAZINE DERIVATIVES PAMLICO PHARMACEUTICAL INC. (US) 2012-06-28 — — WO claimed
EP-2635578-B1 2-ARYLIMIDAZO[1,2-B]PYRIDAZINE, 2-PHENYLIMIDAZO[1,2-A]PYRIDINE, AND 2-PHENYLIMIDAZO[1,2-A]PYRAZINE DERIVATIVES HENGRUI USA LTD (US) 2015-12-16 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120178751-A1 2-ARYLIMIDAZO[1,2-B]PYRIDAZINE, 2-PHENYLIMIDAZO[1,2-A]PYRIDINE, AND 2-PHENYLIMIDAZO[1,2-A]PYRAZINE DERIVATIVES PRXL2A, CDK2, CCNA2 PTGER4 1765/4885FGFR1 660/4885TP53 10/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.