SCHEMBL9956185

SCHEMBL9956185

Nc1nc2c(c(=O)[nH]1)C=CCC2

nearest known ligand 0.41

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TYMS P04818 17/20 0.41
PNP P00491 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19673807 0.79 PARP1 (0.45) TYMS
SCHEMBL1034105 0.76 HTT (0.38)
SCHEMBL8559330 0.74 TYMS (0.33) TYMS
SCHEMBL1033816 0.73 TNKS (0.46)
SCHEMBL12342904 0.72 HPGD (0.55)
SCHEMBL1032368 0.71 TNKS2 (0.52)
SCHEMBL1082497 0.70 GPR84 (0.43)
SCHEMBL1033073 0.69 KDM4E (0.40) TYMS
SCHEMBL9957231 0.69 NOS1 (0.38) PNP
SCHEMBL9544423 0.66 HSD17B10 (0.33) PNP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012085166-A1 METABOTROPIC GLUTAMATE RECEPTOR MODULATORS MERZ PHARMA GMBH & CO. KGAA (DE) 2012-06-28 WO disclosed