Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.75 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.36 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.33 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.33 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9959182 | 0.94 | FAAH (0.71) | FAAHPLA2G2ASCN10AALDH1A1MAPT | |
| SCHEMBL9959139 | 0.94 | FAAH (0.65) | FAAHPLA2G2AALDH1A1MAPTPKM | |
| SCHEMBL9960034 | 0.92 | FAAH (0.62) | FAAHPLA2G2ASCN10AMAPT | |
| SCHEMBL10242361 | 0.91 | FAAH (0.62) | FAAHPLA2G2ASCN10AALDH1A1MAPT | |
| SCHEMBL9960948 | 0.90 | FAAH (0.60) | FAAHPLA2G2ASCN10AALDH1A1MAPT | |
| SCHEMBL9960092 | 0.90 | FAAH (0.60) | FAAHPLA2G2ASCN10AMAPTMAPK3 | |
| SCHEMBL9960013 | 0.90 | FAAH (0.60) | FAAHPLA2G2ASCN10AALDH1A1MAPT | |
| SCHEMBL10242573 | 0.90 | FAAH (0.60) | FAAHPLA2G2ASCN10AALDH1A1MAPT | |
| SCHEMBL9960003 | 0.89 | FAAH (0.59) | FAAHSCN10AMAPK3RAB9AKCNK3 | |
| SCHEMBL9960022 | 0.88 | FAAH (0.58) | FAAHPLA2G2ASCN10AMAPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012088431-A1 | FAAH INHIBITORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2012-06-28 | — | — | WO | disclosed |
| WO-2012088431-A1 | FAAH INHIBITORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2012-06-28 | — | — | WO | disclosed |