Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.58 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.34 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.34 |
| ▸ | AXL | P30530 | 2/20 | 0.33 |
| ▸ | AURKA | O14965 | 2/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.33 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.33 |
| ▸ | MET | P08581 | 5/20 | 0.32 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.31 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | INSR | P06213 | 1/20 | 0.31 |
| ▸ | LCK | P06239 | 1/20 | 0.31 |
| ▸ | RET | P07949 | 1/20 | 0.31 |
| ▸ | IGF1R | P08069 | 1/20 | 0.31 |
| ▸ | KIT | P10721 | 1/20 | 0.31 |
| ▸ | PIM1 | P11309 | 1/20 | 0.31 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.31 |
| ▸ | SRC | P12931 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9960948 | 0.94 | FAAH (0.60) | FAAHSCN10AP2RX3MAPK3PLA2G2A | |
| SCHEMBL9960092 | 0.92 | FAAH (0.60) | FAAHSCN10AGRM4MAPK3KDR | |
| SCHEMBL10242573 | 0.92 | FAAH (0.60) | FAAHSCN10AGRM4MAPK3PLA2G2A | |
| SCHEMBL9960013 | 0.91 | FAAH (0.60) | FAAHSCN10AGRM4MAPK3PLA2G2A | |
| SCHEMBL10242361 | 0.89 | FAAH (0.62) | FAAHSCN10AMAPK3PLA2G2ASORT1 | |
| SCHEMBL9956255 | 0.88 | FAAH (0.75) | FAAHSCN10AMAPK3PLA2G2A | |
| SCHEMBL9959182 | 0.88 | FAAH (0.71) | FAAHSCN10APLA2G2A | |
| SCHEMBL9959139 | 0.87 | FAAH (0.65) | FAAHPLA2G2A | |
| SCHEMBL9960034 | 0.87 | FAAH (0.62) | FAAHSCN10APLA2G2A | |
| SCHEMBL9959333 | 0.87 | FAAH (0.77) | FAAHP2RX3AXLAURKAAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012088431-A1 | FAAH INHIBITORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2012-06-28 | — | — | WO | disclosed |
| WO-2012088431-A1 | FAAH INHIBITORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2012-06-28 | — | — | WO | disclosed |