Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 5/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.34 |
| ▸ | TTK | P33981 | 1/20 | 0.34 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.34 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.34 |
| ▸ | LDLR | P01130 | 2/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9955447 | 0.86 | NPC1 (0.39) | NPC1RAB9ARXFP1RIPK1CSNK1D | |
| SCHEMBL9956029 | 0.84 | MAPT (0.42) | NPC1RAB9ATP53RXFP1MAPT | |
| SCHEMBL9954927 | 0.84 | TP53 (0.43) | NPC1RAB9ATP53RXFP1MAPT | |
| SCHEMBL9955659 | 0.84 | HDAC1 (0.43) | RAB9ATP53RXFP1MAPTLMNA | |
| SCHEMBL9957088 | 0.84 | TGFBR1 (0.39) | NPC1RAB9ALMNAKDM4EALDH1A1 | |
| SCHEMBL9955957 | 0.83 | TGFBR1 (0.38) | NPC1RAB9ARXFP1MAPTRIPK1 | |
| SCHEMBL9957485 | 0.82 | MAPT (0.38) | NPC1RAB9ATP53RXFP1MAPT | |
| SCHEMBL9956009 | 0.78 | KDR (0.37) | NPC1RAB9ARIPK1 | |
| SCHEMBL9957147 | 0.75 | CSNK1D (0.44) | NPC1RAB9ATP53RXFP1MAPT | |
| SCHEMBL9956513 | 0.74 | RXFP1 (0.39) | TP53RXFP1MAPTLMNACSNK1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2635578-A1 | 2-ARYLIMIDAZO[1,2-B]PYRIDAZINE, 2-PHENYLIMIDAZO[1,2-A]PYRIDINE, AND 2-PHENYLIMIDAZO[1,2-A]PYRAZINE DERIVATIVES | Hengrui (USA) Ltd. (US) | 2013-09-11 | — | — | EP | claimed |
| WO-2012088411-A1 | 2-ARYLIMIDAZO[1,2-B]PYRIDAZINE, 2-PHENYLIMIDAZO[1,2-A]PYRIDINE, AND 2-PHENYLIMIDAZO[1,2-A]PYRAZINE DERIVATIVES | PAMLICO PHARMACEUTICAL INC. (US) | 2012-06-28 | — | — | WO | claimed |
| EP-2635578-B1 | 2-ARYLIMIDAZO[1,2-B]PYRIDAZINE, 2-PHENYLIMIDAZO[1,2-A]PYRIDINE, AND 2-PHENYLIMIDAZO[1,2-A]PYRAZINE DERIVATIVES | HENGRUI USA LTD (US) | 2015-12-16 | — | — | EP | disclosed |