Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.37 |
| ▸ | GSTM2 | P28161 | 1/20 | 0.37 |
| ▸ | WDR5 | P61964 | 1/20 | 0.37 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.37 |
| ▸ | HPGDS | O60760 | 3/20 | 0.36 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.35 |
| ▸ | CSNK1E | P49674 | 3/20 | 0.35 |
| ▸ | KDR | P35968 | 2/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.34 |
| ▸ | SMO | Q99835 | 2/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9957088 | 0.94 | TGFBR1 (0.39) | NPC1RAB9AWDR5RIPK1TGFBR1 | |
| SCHEMBL9956009 | 0.89 | KDR (0.37) | NPC1RAB9AWDR5RIPK1TGFBR1 | |
| SCHEMBL9955957 | 0.88 | TGFBR1 (0.38) | NPC1RAB9AWDR5RIPK1TGFBR1 | |
| SCHEMBL9956895 | 0.86 | NPC1 (0.38) | NPC1RAB9ARIPK1CSNK1DCSNK1E | |
| SCHEMBL9956960 | 0.82 | CSNK1D (0.42) | RIPK1CSNK1DCSNK1EMAPK14SMO | |
| SCHEMBL9956631 | 0.82 | PIK3CG (0.42) | RIPK1CSNK1DCSNK1EPIK3CGMAPK14 | |
| SCHEMBL9955915 | 0.81 | CAMKK2 (0.44) | RIPK1CSNK1DCSNK1ERXFP1 | |
| SCHEMBL9957221 | 0.81 | CSNK1D (0.44) | RIPK1CSNK1DCSNK1ERXFP1 | |
| SCHEMBL10277139 | 0.80 | TGFBR1 (0.37) | NPC1RAB9AWDR5TGFBR1CSNK1D | |
| SCHEMBL9955473 | 0.80 | ALDH1A1 (0.46) | NPC1RAB9ARIPK1CSNK1DCSNK1E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2635578-A1 | 2-ARYLIMIDAZO[1,2-B]PYRIDAZINE, 2-PHENYLIMIDAZO[1,2-A]PYRIDINE, AND 2-PHENYLIMIDAZO[1,2-A]PYRAZINE DERIVATIVES | Hengrui (USA) Ltd. (US) | 2013-09-11 | — | — | EP | claimed |
| US-20120178751-A1 | 2-ARYLIMIDAZO[1,2-B]PYRIDAZINE, 2-PHENYLIMIDAZO[1,2-A]PYRIDINE, AND 2-PHENYLIMIDAZO[1,2-A]PYRAZINE DERIVATIVES | HENGRUI (USA), LTD. | 2012-07-12 | — | — | US | claimed |
| WO-2012088411-A1 | 2-ARYLIMIDAZO[1,2-B]PYRIDAZINE, 2-PHENYLIMIDAZO[1,2-A]PYRIDINE, AND 2-PHENYLIMIDAZO[1,2-A]PYRAZINE DERIVATIVES | PAMLICO PHARMACEUTICAL INC. (US) | 2012-06-28 | — | — | WO | claimed |
| US-10066164-B2 | Semiconductor nanocrystals used with LED sources | NAJING TECHNOLOGY CORPORATION LIMITED (CN) | 2018-09-04 | — | — | US | disclosed |
| US-9580647-B2 | Simultaneous optimization of absorption and emission of nanocrystals | NAJING TECHNOLOGY CORPORATION LIMITED (CN) | 2017-02-28 | — | — | US | disclosed |
| EP-2635578-B1 | 2-ARYLIMIDAZO[1,2-B]PYRIDAZINE, 2-PHENYLIMIDAZO[1,2-A]PYRIDINE, AND 2-PHENYLIMIDAZO[1,2-A]PYRAZINE DERIVATIVES | HENGRUI USA LTD (US) | 2015-12-16 | — | — | EP | disclosed |
| US-20130134366-A1 | Simultaneous Optimization of Absorption and Emission of Nanocrystals | NAJING TECHNOLOGY CORPORATION LIMITED (CN) | 2013-05-30 | — | — | US | disclosed |
| US-20120175588-A1 | SEMICONDUCTOR NANOCRYSTALS USED WITH LED SOURCES | NAJING TECHNOLOGY CORPORATION LIMITED (CN) | 2012-07-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120178751-A1 | 2-ARYLIMIDAZO[1,2-B]PYRIDAZINE, 2-PHENYLIMIDAZO[1,2-A]PYRIDINE, AND 2-PHENYLIMIDAZO[1,2-A]PYRAZINE DERIVATIVES | PRXL2A, CDK2, CCNA2 | NPC1 2650/4885RAB9A 3019/4885GSTP1 2009/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.