Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | PTGIR | P43119 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27926087 | 0.88 | DPP4 (0.41) | HIF1AKDM4EALDH1A1BRD4BRD9 | |
| SCHEMBL9957126 | 0.81 | KDM4E (0.43) | HIF1AKDM4EALDH1A1BRD4GAA | |
| SCHEMBL9955454 | 0.79 | LPAR1 (0.47) | HIF1AKDM4EALDH1A1KMT2APKM | |
| SCHEMBL14397416 | 0.78 | HIF1A (0.43) | HIF1AKDM4EALDH1A1GAAKMT2A | |
| SCHEMBL13714044 | 0.77 | L3MBTL1 (0.41) | NR4A3GAAKMT2ALMNAL3MBTL1 | |
| SCHEMBL9697757 | 0.76 | PKM (0.41) | HIF1AKDM4EALDH1A1BRD4BRD9 | |
| SCHEMBL6786512 | 0.75 | BPTF (0.48) | KDM4EALDH1A1BRD4BRD9GAA | |
| SCHEMBL28016014 | 0.75 | BPTF (0.42) | HIF1AKDM4EBRD4BRD9GAA | |
| SCHEMBL14398377 | 0.73 | L3MBTL1 (0.47) | HIF1AKDM4EALDH1A1GAAKMT2A | |
| SCHEMBL21937795 | 0.70 | CREBBP (0.70) | BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655323-A1 | INGENOL-3-ACYLATES III AND INGENOL-3-CARBAMATES | LEO LABORATORIES LIMITED (IE) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012083953-A1 | INGENOL-3-ACYLATES III AND INGENOL-3-CARBAMATES | LEO PHARMA A/S (DK) | 2012-06-28 | — | — | WO | disclosed |