Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 7/20 | 1.00 |
| ▸ | HDAC1 | Q13547 | 10/20 | 0.69 |
| ▸ | HDAC3 | O15379 | 7/20 | 0.69 |
| ▸ | HDAC2 | Q92769 | 7/20 | 0.69 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.69 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.69 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.69 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.69 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.69 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.69 |
| ▸ | HDAC9 | Q9UKV0 | 5/20 | 0.69 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 0.69 |
| ▸ | KDM1A | O60341 | 1/20 | 0.68 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.68 |
| ▸ | F3 | P13726 | 1/20 | 0.68 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.68 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12633524 | 0.94 | NAMPT (0.89) | NAMPTHDAC1HDAC3HDAC2HDAC4 | |
| SCHEMBL12090170 | 0.89 | NAMPT (0.81) | NAMPTHDAC1HDAC3HDAC2HDAC4 | |
| SCHEMBL12090295 | 0.88 | NAMPT (0.79) | NAMPTHDAC1HDAC3HDAC2HDAC4 | |
| SCHEMBL996878 | 0.87 | NAMPT (0.78) | NAMPTHDAC1HDAC3HDAC2HDAC4 | |
| SCHEMBL998206 | 0.85 | NAMPT (1.00) | NAMPT | |
| SCHEMBL1435653 | 0.84 | HDAC1 (0.73) | NAMPTHDAC1HDAC3HDAC2HDAC4 | |
| SCHEMBL1435352 | 0.83 | NAMPT (0.71) | NAMPTHDAC1HDAC3HDAC2HDAC4 | |
| SCHEMBL7742679 | 0.82 | NAMPT (0.68) | NAMPTHDAC1HDAC3HDAC2HDAC4 | |
| SCHEMBL968903 | 0.82 | POLB (0.71) | NAMPT | |
| SCHEMBL5790114 | 0.82 | HDAC1 (0.74) | NAMPTHDAC1HDAC3HDAC2HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9296732-B2 | Substituted benzamides and their uses | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2016-03-29 | — | — | US | disclosed |
| US-20150329503-A1 | SUBSTITUTED BENZAMIDES AND THEIR USES | UNIV LELAND STANFORD JUNIOR (US) | 2015-11-19 | — | — | US | disclosed |
| US-9085570-B2 | Substituted benzamides and their uses | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2015-07-21 | — | — | US | disclosed |
| EP-2456435-B1 | HETEROARYL BENZAMIDES, COMPOSITIONS AND METHODS OF USE | UNIV LELAND STANFORD JUNIOR (US) | 2015-06-24 | — | — | EP | disclosed |
| US-20150072976-A1 | SUBSTITUTED BENZAMIDES AND THEIR USES | ARAVIVE BIOLOGICS, INC. | 2015-03-12 | — | — | US | disclosed |
| EP-2838534-A2 | SUBSTITUTED BENZAMIDES AND THEIR USES | The Board of Trustees of The Leland Stanford Junior University (US) | 2015-02-25 | — | — | EP | disclosed |
| US-20140024649-A1 | Substituted Benzamides and Their Uses | AUCKLAND UNISERVICES LIMITED (NZ) | 2014-01-23 | — | — | US | disclosed |
| WO-2013155338-A2 | SUBSTITUTED BENZAMIDES AND THEIR USES | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2013-10-17 | — | — | WO | disclosed |
| CN-103327972-A | Substituted benzamides and their uses | UNIV LELAND STANFORD JUNIOR | 2013-09-25 | — | — | CN | disclosed |
| EP-2627324-A2 | SUBSTITUTED BENZAMIDES AND THEIR USES | The Board of Trustees of The Leland Stanford Junior University (US) | 2013-08-21 | — | — | EP | disclosed |
| US-20120225862-A1 | HETEROARYL BENZAMIDES, COMPOSITIONS AND METHODS OF USE | AUCKLAND UNIVSERVICES LIMITED (NZ) | 2012-09-06 | — | — | US | disclosed |
| EP-2456435-A1 | HETEROARYL BENZAMIDES, COMPOSITIONS AND METHODS OF USE | The Board of Trustees of The Leland Stanford Junior University (US) | 2012-05-30 | — | — | EP | disclosed |
| WO-2012051117-A2 | SUBSTITUTED BENZAMIDES AND THEIR USES | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2012-04-19 | — | — | WO | disclosed |
| WO-2011011514-A1 | HETEROARYL BENZAMIDES, COMPOSITIONS AND METHODS OF USE | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2011-01-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150329503-A1 | SUBSTITUTED BENZAMIDES AND THEIR USES | NISCH, BTD, NAAA | NAMPT 199/4885HDAC1 512/4885HDAC3 204/4885 |
| US-20120225862-A1 | HETEROARYL BENZAMIDES, COMPOSITIONS AND METHODS OF USE | BRDT, NISCH, PAICS | NAMPT 624/4885HDAC1 697/4885HDAC3 182/4885 |
| US-20140024649-A1 | Substituted Benzamides and Their Uses | NISCH, BTD, NAAA | NAMPT 199/4885HDAC1 512/4885HDAC3 204/4885 |
| US-20150072976-A1 | SUBSTITUTED BENZAMIDES AND THEIR USES | NISCH, BTD, NAAA | NAMPT 199/4885HDAC1 512/4885HDAC3 204/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.