Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.71 |
| ▸ | NAMPT | P43490 | 3/20 | 0.68 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.61 |
| ▸ | MGLL | Q99685 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | PKM | P14618 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.55 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11563747 | 0.91 | NAMPT (0.77) | POLBNAMPTCHRNA7KMT2AMEN1 | |
| SCHEMBL1665313 | 0.91 | POLB (0.67) | POLBNAMPTCHRNA7KMT2AMEN1 | |
| SCHEMBL27706331 | 0.87 | NAMPT (0.60) | POLBNAMPTCHRNA7KMT2AMEN1 | |
| SCHEMBL19993034 | 0.85 | POLB (0.70) | POLBNAMPTKMT2AMEN1LMNA | |
| SCHEMBL5348225 | 0.85 | ALDH1A1 (0.60) | POLBNAMPTKMT2AMEN1LMNA | |
| Benzyl Phenylcarbamate SCHEMBL1222943 | 0.84 | POLB (0.78) | POLBLMNAALDH1A1MAPTMGLL | |
| SCHEMBL1334862 | 0.83 | POLB (0.88) | POLBNAMPTCHRNA7LMNAMAPT | |
| SCHEMBL13679756 | 0.83 | POLB (1.00) | POLBNAMPTCHRNA7LMNAALDH1A1 | |
| SCHEMBL5347283 | 0.82 | KMT2A (0.63) | POLBNAMPTKMT2AMEN1LMNA | |
| SCHEMBL995725 | 0.82 | NAMPT (1.00) | NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108948019-B | Focal adhesion kinase inhibitors and uses thereof | 广东东阳光药业有限公司 | 2022-07-08 | — | — | CN | disclosed |
| CN-114245796-A | Imidazo [1,2-a ] pyridinyl derivatives and their use in the treatment of disease | 比奥根MA公司 | 2022-03-25 | — | — | CN | disclosed |
| CN-109195965-A | The inhibitor that WDR5 protein-protein combines | 普罗佩纶治疗公司 | 2019-01-11 | — | — | CN | disclosed |
| CN-103073460-B | Be applicable to treat the aromatic substance that the arylsulfonyl ylmethyl of the disease responded for the adjustment of dopamine D 3 receptor or aryl sulfonic acid amides replace | AbbVie Deutschland GmbH & Co. KG (DE) | 2015-09-09 | — | — | CN | disclosed |
| CN-101679266-B | PIM kinase inhibitors and methods of their use | NOVARTIS AG | 2015-05-06 | — | — | CN | disclosed |
| CN-104311480-A | Picolinamide derivatives as kinase inhibitors | NOVARTIS AG | 2015-01-28 | — | — | CN | disclosed |
| CN-104098559-A | PIM kinase inhibitors and methods of their use | NOVARTIS AG | 2014-10-15 | — | — | CN | disclosed |
| CN-102015701-B | PIM kinase inhibitors and methods of use thereof | NOVARTIS AG | 2014-07-23 | — | — | CN | disclosed |
| CN-103073460-A | Arylsulfonylmethyl or arylsulfonamide substituted aromatic compounds suitable for treating disorders that respond to modulation of the dopamine D3 receptor | ABBOTT GMBH & CO KG | 2013-05-01 | — | — | CN | disclosed |
| CN-101068801-B | Arylsulfonylmethyl or arylsulfonamide substituted aromatic compounds suitable for the treatment of disorders which respond to modulation of the dopamine D3 receptor | ABBOTT GMBH & CO KG | 2012-11-14 | — | — | CN | disclosed |
| US-7335753-B2 | Bifunctional heterocyclic compounds and methods of making and using same | RIB-X PHARMACEUTICALS, INC. (US) | 2008-02-26 | — | — | US | disclosed |
| US-7335753-B2 | Bifunctional heterocyclic compounds and methods of making and using same | RIB-X PHARMACEUTICALS, INC. (US) | 2008-02-26 | — | — | US | disclosed |
| CN-101068801-A | Arylsulfonylmethyl or arylsulfonamide substituted aromatic compounds suitable for the treatment of disorders which respond to modulation of the dopamine D3 receptor | ABBOTT GMBH & CO KG (DE) | 2007-11-07 | — | — | CN | disclosed |
| CN-1343206-A | Cyclocompound | FUJISAWA PHARMACEUTICAL CO (JP) | 2002-04-03 | — | — | CN | disclosed |
| EP-0739204-A4 | PIPERIDINES, PYRROLIDINES AND HEXAHYDRO-1H-AZEPINES PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO INC (US) | 2000-03-15 | — | — | EP | disclosed |
| US-5721250-A | ADMINISTERING TO TREAT PHYSIOLOGICAL AND MEDICAL CONDITIONS CHARACTERIZED BY A DEFICIENCY IN GROWTH HORMONE SECRETION: SHORT STATURE | MERCK & CO. INC. (US) | 1998-02-24 | — | — | US | disclosed |
| US-5622973-A | BONE DISORDERS | MERCK & CO., INC. (US) | 1997-04-22 | — | — | US | disclosed |
| EP-0739204-A1 | PIPERIDINES, PYRROLIDINES AND HEXAHYDRO-1H-AZEPINES PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO. INC. (US) | 1996-10-30 | — | — | EP | disclosed |
| US-5492916-A | Di- and tri-substituted piperidines, pyrrolidines and hexahydro-1H-azepines promote release of growth hormone | MERCK & CO., INC. (US) | 1996-02-20 | — | — | US | disclosed |
| WO-1995013069-A1 | PIPERIDINES, PYRROLIDINES AND HEXAHYDRO-1H-AZEPINES PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO., INC. (US) | 1995-05-18 | — | — | WO | disclosed |