Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.69 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.34 |
| ▸ | EP300 | Q09472 | 1/20 | 0.34 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11649419 | 0.82 | HSD17B10 (1.00) | HSD17B10HPGDLMNAALDH1A1MAPK1 | |
| SCHEMBL9956809 | 0.78 | HSD17B10 (0.43) | HSD17B10HPGDALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL11646460 | 0.77 | HPGD (0.66) | HSD17B10HPGDLMNAALDH1A1MAPK1 | |
| SCHEMBL9956088 | 0.77 | HSD17B10 (0.42) | HSD17B10HPGDLMNAMAPK1CYP1A2 | |
| SCHEMBL9956376 | 0.77 | HSD17B10 (0.42) | HSD17B10HPGDLMNAALDH1A1MAPT | |
| SCHEMBL10058644 | 0.69 | HSD17B10 (0.71) | HSD17B10HPGDLMNAALDH1A1MAPK1 | |
| SCHEMBL13303521 | 0.69 | ALDH1A1 (0.39) | HSD17B10HPGDLMNAALDH1A1CYP1A2 | |
| SCHEMBL11649230 | 0.68 | HSD17B10 (0.52) | HSD17B10LMNACYP1A2HCAR2 | |
| SCHEMBL11645948 | 0.67 | HSD17B10 (0.72) | HSD17B10HPGDLMNAALDH1A1MAPK1 | |
| SCHEMBL11647887 | 0.67 | HPGD (0.53) | HSD17B10HPGDLMNAALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655323-A1 | INGENOL-3-ACYLATES III AND INGENOL-3-CARBAMATES | LEO LABORATORIES LIMITED (IE) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012083953-A1 | INGENOL-3-ACYLATES III AND INGENOL-3-CARBAMATES | LEO PHARMA A/S (DK) | 2012-06-28 | — | — | WO | disclosed |