Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | POLB | P06746 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 5/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9955516 | 0.85 | ALDH1A1 (0.46) | HSD17B10MAPTPOLBLMNAALDH1A1 | |
| SCHEMBL9957516 | 0.77 | HSD17B10 (0.69) | HSD17B10MAPTPOLBLMNAALDH1A1 | |
| SCHEMBL9956809 | 0.71 | HSD17B10 (0.43) | HSD17B10MAPTALDH1A1NPSR1HPGD | |
| SCHEMBL13303521 | 0.63 | ALDH1A1 (0.39) | HSD17B10MAPTPOLBLMNAALDH1A1 | |
| SCHEMBL11645883 | 0.63 | HSD17B10 (0.65) | HSD17B10MAPTPOLBLMNAALDH1A1 | |
| SCHEMBL5518084 | 0.63 | HSD17B10 (0.46) | HSD17B10MAPTPOLBLMNAALDH1A1 | |
| SCHEMBL8203697 | 0.62 | HPGD (0.59) | MAPTPOLBLMNAALDH1A1NPC1 | |
| SCHEMBL1126546 | 0.60 | HPGD (0.64) | MAPTLMNAALDH1A1NPC1RAB9A | |
| SCHEMBL16417100 | 0.60 | NOTUM (0.50) | LMNA | |
| SCHEMBL11646460 | 0.60 | HPGD (0.66) | HSD17B10MAPTPOLBLMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655323-A1 | INGENOL-3-ACYLATES III AND INGENOL-3-CARBAMATES | LEO LABORATORIES LIMITED (IE) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012083953-A1 | INGENOL-3-ACYLATES III AND INGENOL-3-CARBAMATES | LEO PHARMA A/S (DK) | 2012-06-28 | — | — | WO | disclosed |