Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9957824 | 0.81 | PDE4D (0.47) | PDE4DRAB9AALDH1A1MAPK1MAPT | |
| SCHEMBL29295146 | 0.79 | MAPK1 (0.62) | PDE4DRAB9AALDH1A1MAPK1MAPT | |
| SCHEMBL3573365 | 0.78 | PDE4D (0.44) | PDE4DRAB9AALDH1A1L3MBTL1MAPK1 | |
| SCHEMBL11405426 | 0.78 | RAB9A (0.48) | PDE4DRAB9AALDH1A1MAPK1MAPT | |
| SCHEMBL2206209 | 0.77 | MAPK1 (0.64) | ALDH1A1L3MBTL1MAPK1MAPTKDM4E | |
| SCHEMBL4800541 | 0.75 | FHIT (0.50) | ALDH1A1MAPK1MAPTKDM4EGAA | |
| SCHEMBL1527760 | 0.74 | PDE4D (0.53) | PDE4DRAB9AALDH1A1L3MBTL1MAPT | |
| SCHEMBL1527674 | 0.72 | ALDH1A1 (0.59) | PDE4DRAB9AALDH1A1MAPK1MAPT | |
| SCHEMBL3381063 | 0.72 | PDE4D (0.51) | PDE4DRAB9AALDH1A1MAPK1MAPT | |
| SCHEMBL22230710 | 0.72 | PDE4D (0.51) | PDE4DRAB9AALDH1A1MAPK1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1984340-B1 | ANTHRANILAMIDE/2-AMINO-HETEROARENE CARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-06-27 | — | — | EP | disclosed |