Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | CA12 | O43570 | 1/20 | 0.54 |
| ▸ | CA1 | P00915 | 1/20 | 0.54 |
| ▸ | CA2 | P00918 | 1/20 | 0.54 |
| ▸ | CA4 | P22748 | 1/20 | 0.54 |
| ▸ | LTA4H | P09960 | 1/20 | 0.54 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | MPO | P05164 | 1/20 | 0.48 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.44 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3584471 | 0.94 | L3MBTL1 (0.58) | L3MBTL1KDM4EALDH1A1CA12CA1 | |
| SCHEMBL3577596 | 0.84 | CA12 (0.54) | L3MBTL1KDM4ECA12CA1CA2 | |
| SCHEMBL3573452 | 0.78 | CA12 (0.51) | KDM4ECA12CA1CA2CA4 | |
| SCHEMBL5177540 | 0.78 | JAK2 (0.39) | L3MBTL1CYP1A2CYP2D6CYP2C19CYP3A4 | |
| SCHEMBL10399489 | 0.78 | KDM4E (0.84) | L3MBTL1KDM4EALDH1A1CA12CA1 | |
| SCHEMBL3230910 | 0.77 | CYP1A2 (0.55) | CYP1A2CYP2D6CYP2C19CYP2C9TAAR1 | |
| SCHEMBL184505 | 0.77 | LMNA (0.50) | L3MBTL1ALDH1A1LMNACYP2D6CYP2C19 | |
| SCHEMBL3240146 | 0.76 | L3MBTL1 (0.69) | L3MBTL1KDM4EALDH1A1CA12CA1 | |
| SCHEMBL28767215 | 0.75 | PTPN1 (0.40) | ALDH1A1CHRM2 | |
| SCHEMBL6495269 | 0.75 | SPHK1 (0.51) | ALDH1A1CYP2C9CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1984340-B1 | ANTHRANILAMIDE/2-AMINO-HETEROARENE CARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-06-27 | — | — | EP | disclosed |
| CN-101379036-B | Anthranilamide/2-amino-heteroarene carboxamide derivatives | HOFFMANN LA ROCHE | 2011-06-01 | — | — | CN | disclosed |
| CN-101379036-A | Anthranilamide/2-amino-heteroarene carboxamide derivatives | HOFFMANN LA ROCHE (CH) | 2009-03-04 | — | — | CN | disclosed |