Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 12/20 | 0.44 |
| ▸ | HCRTR2 | O43614 | 12/20 | 0.44 |
| ▸ | DPP4 | P27487 | 1/20 | 0.42 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.42 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.42 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9957907 | 0.96 | HCRTR1 (0.44) | HCRTR1HCRTR2DPP4DPP8DPP9 | |
| SCHEMBL9958187 | 0.88 | HCRTR1 (0.45) | HCRTR1HCRTR2DPP4DPP8DPP9 | |
| SCHEMBL9957542 | 0.85 | HCRTR1 (0.50) | HCRTR1HCRTR2DPP4DPP8DPP9 | |
| SCHEMBL9956636 | 0.82 | DPP4 (0.38) | HCRTR1HCRTR2DPP4DPP8DPP9 | |
| SCHEMBL9956083 | 0.82 | DPP4 (0.38) | HCRTR1HCRTR2DPP4DPP8DPP9 | |
| SCHEMBL9957068 | 0.81 | RET (0.46) | HCRTR1HCRTR2DPP4DPP8DPP9 | |
| SCHEMBL9957065 | 0.81 | RET (0.46) | HCRTR1HCRTR2DPP4DPP8DPP9 | |
| SCHEMBL9957137 | 0.80 | HCRTR1 (0.44) | HCRTR1HCRTR2DPP4DPP8DPP9 | |
| SCHEMBL9957559 | 0.80 | HCRTR1 (0.44) | HCRTR1HCRTR2DPP4DPP8DPP9 | |
| SCHEMBL9957037 | 0.78 | HCRTR1 (0.45) | HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012085852-A1 | 3,8-DIAZA-BICYCLO[4.2.0]OCT-8-YL AMIDES | ACTELION PHARMACEUTICALS LTD (CH) | 2012-06-28 | — | — | WO | disclosed |