SCHEMBL9957065 — predicted protein targets

Predicted protein targets (top 14)

	gene	UniProt	supporting neighbours	confidence
▸	RET	P07949	1/20	0.46

▸	GPR119	Q8TDV5	6/20	0.42

▸	HCRTR1	O43613	5/20	0.41

▸	HCRTR2	O43614	5/20	0.41

▸	MAP4K4	O95819	1/20	0.40

▸	USP30	Q70CQ3	1/20	0.39

▸	DPP4	P27487	1/20	0.39

▸	DPP8	Q6V1X1	1/20	0.39

▸	DPP9	Q86TI2	1/20	0.39

▸	DPP7	Q9UHL4	1/20	0.39

▸	NR1H2	P55055	1/20	0.38

▸	NR1H3	Q13133	1/20	0.38

▸	HDAC3	O15379	1/20	0.37

▸	HDAC2	Q92769	1/20	0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL9957068	1.00	RET (0.46)	RETGPR119HCRTR1HCRTR2MAP4K4
SCHEMBL9957283	0.88	GPR119 (0.50)	RETGPR119HCRTR1HCRTR2DPP4
SCHEMBL9957280	0.88	GPR119 (0.50)	RETGPR119HCRTR1HCRTR2DPP4
SCHEMBL9957734	0.86	RET (0.42)	RETGPR119MAP4K4USP30NR1H2
SCHEMBL9957737	0.86	RET (0.42)	RETGPR119MAP4K4USP30NR1H2
SCHEMBL9957907	0.85	HCRTR1 (0.44)	HCRTR1HCRTR2DPP4DPP8DPP9
SCHEMBL9958172	0.81	HCRTR1 (0.44)	HCRTR1HCRTR2DPP4DPP8DPP9
SCHEMBL1586058	0.78	HCRTR1 (0.51)	HCRTR1HCRTR2
SCHEMBL9957554	0.76	HCRTR1 (0.57)	HCRTR1HCRTR2
SCHEMBL9957079	0.76	HCRTR1 (0.57)	HCRTR1HCRTR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2012085852-A1	3,8-DIAZA-BICYCLO[4.2.0]OCT-8-YL AMIDES	ACTELION PHARMACEUTICALS LTD (CH)	2012-06-28	—	—	WO	disclosed