Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 4/20 | 0.38 |
| ▸ | DPP7 | Q9UHL4 | 4/20 | 0.38 |
| ▸ | DPP8 | Q6V1X1 | 3/20 | 0.38 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 9/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 9/20 | 0.36 |
| ▸ | JAK3 | P52333 | 4/20 | 0.36 |
| ▸ | LCK | P06239 | 2/20 | 0.35 |
| ▸ | BTK | Q06187 | 2/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9956636 | 0.92 | DPP4 (0.38) | DPP4DPP7DPP8DPP9HCRTR1 | |
| SCHEMBL9957559 | 0.88 | HCRTR1 (0.44) | DPP4DPP7DPP8DPP9HCRTR1 | |
| SCHEMBL9958187 | 0.85 | HCRTR1 (0.45) | DPP4DPP7DPP8DPP9HCRTR1 | |
| SCHEMBL9957907 | 0.84 | HCRTR1 (0.44) | DPP4DPP7DPP8DPP9HCRTR1 | |
| SCHEMBL9958172 | 0.82 | HCRTR1 (0.44) | DPP4DPP7DPP8DPP9HCRTR1 | |
| SCHEMBL9957137 | 0.81 | HCRTR1 (0.44) | DPP4DPP7DPP8DPP9HCRTR1 | |
| SCHEMBL9957542 | 0.80 | HCRTR1 (0.50) | DPP4DPP7DPP8DPP9HCRTR1 | |
| SCHEMBL9957734 | 0.78 | RET (0.42) | MAP4K4 | |
| SCHEMBL9957737 | 0.78 | RET (0.42) | MAP4K4 | |
| Hydrochloric Acid SCHEMBL9959386 | 0.75 | CHRNB2 (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012085852-A1 | 3,8-DIAZA-BICYCLO[4.2.0]OCT-8-YL AMIDES | ACTELION PHARMACEUTICALS LTD (CH) | 2012-06-28 | — | — | WO | disclosed |