Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.44 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.41 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.41 |
| ▸ | CLK1 | P49759 | 2/20 | 0.41 |
| ▸ | ALOX5AP | P20292 | 8/20 | 0.40 |
| ▸ | FEN1 | P39748 | 6/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.40 |
| ▸ | DHFR | P00374 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3569775 | 0.80 | MAP4K4 (0.41) | ADORA2AADORA1ALOX5APFEN1MAP4K4 | |
| SCHEMBL9957837 | 0.78 | KIF18A (0.47) | ALOX5APFEN1 | |
| SCHEMBL3571995 | 0.75 | DHODH (0.42) | ADORA2AADORA1ALOX5APFEN1MAP4K4 | |
| SCHEMBL5327094 | 0.75 | ADORA1 (0.69) | ADORA2AADORA1DHFR | |
| SCHEMBL9958759 | 0.74 | LRRK2 (0.44) | — | |
| SCHEMBL5318644 | 0.72 | ADORA2A (0.60) | ADORA2AADORA1ALOX5APFEN1MAP4K4 | |
| SCHEMBL29818212 | 0.72 | KIF11 (0.59) | CLK1ALOX5APFEN1MAP4K4 | |
| SCHEMBL3570340 | 0.71 | MAP4K4 (0.46) | ADORA2AADORA1ALOX5APFEN1MAP4K4 | |
| SCHEMBL3569085 | 0.70 | ALOX5AP (0.41) | ADORA2AADORA1CLK1ALOX5APFEN1 | |
| SCHEMBL3562521 | 0.70 | MAP4K4 (0.45) | MAP4K4PIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2468727-A1 | Pyridine and pyrimidine derivatives as MGLUR2 antagonists | F. Hoffmann-La Roche AG (CH) | 2012-06-27 | — | — | EP | claimed |