Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 11/20 | 0.67 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.44 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.40 |
| ▸ | ALPL | P05186 | 1/20 | 0.40 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | TYK2 | P29597 | 1/20 | 0.39 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9931386 | 0.99 | PTGES (0.66) | PTGESLOXL2KLKB1ALPLFFAR2 | |
| SCHEMBL9931451 | 0.81 | PTGES (1.00) | PTGESFFAR2 | |
| Ly-3031207 SCHEMBL9931208 | 0.81 | PTGES (1.00) | PTGES | |
| SCHEMBL9960827 | 0.80 | PTGES (0.73) | PTGESALPLFFAR2JAK2JAK1 | |
| SCHEMBL9931625 | 0.79 | PTGES (0.71) | PTGES | |
| SCHEMBL9931813 | 0.78 | PTGES (1.00) | PTGES | |
| SCHEMBL9932157 | 0.78 | PTGES (0.81) | PTGES | |
| SCHEMBL18912321 | 0.77 | LOXL2 (0.47) | PTGESLOXL2 | |
| SCHEMBL9931961 | 0.77 | PTGES (0.68) | PTGES | |
| SCHEMBL3596142 | 0.69 | ALDH1A1 (0.54) | PTGESALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655335-A1 | NOVEL IMIDAZOLE-2-BENZAMIDE COMPOUNDS USEFUL FOR THE TREATMENT OF OSTEOARTHRITIS | Eli Lilly and Company (US) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012087771-A1 | NOVEL IMIDAZOLE-2-BENZAMIDE COMPOUNDS USEFUL FOR THE TREATMENT OF OSTEOARTHRITIS | ELI LILLY AND COMPANY (US) | 2012-06-28 | — | — | WO | disclosed |