Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 15/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.39 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
| ▸ | PLAU | P00749 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12090318 | 0.90 | ELANE (0.48) | ELANEF2PLAU | |
| SCHEMBL257733 | 0.89 | ELANE (0.47) | ELANEF2PLAUALDH1A1 | |
| SCHEMBL9959964 | 0.88 | ELANE (0.47) | ELANEGABRG2GABRB3GABRA5F2 | |
| SCHEMBL257431 | 0.84 | ELANE (0.44) | ELANEGABRG2GABRB3GABRA5GABRA1 | |
| SCHEMBL2237767 | 0.81 | HTR3A (0.46) | ELANEMAPTGABRG2GABRB3GABRA5 | |
| SCHEMBL29484986 | 0.81 | OPRK1 (0.42) | ELANEMAPT | |
| SCHEMBL25883005 | 0.81 | OPRK1 (0.42) | ELANEMAPT | |
| SCHEMBL2144493 | 0.80 | GAA (0.41) | — | |
| SCHEMBL30040235 | 0.80 | GAA (0.41) | — | |
| SCHEMBL29593200 | 0.80 | ELANE (0.51) | ELANEMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655370-A1 | COMPOSITIONS AND METHODS FOR MODULATING FXR | IRM LLC (BM) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012087519-A1 | COMPOSITIONS AND METHODS FOR MODULATING FXR | IRM LLC (BM) | 2012-06-28 | — | — | WO | disclosed |