Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.54 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.54 |
| ▸ | CDK2 | P24941 | 2/20 | 0.54 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.54 |
| ▸ | AXL | P30530 | 7/20 | 0.52 |
| ▸ | TYRO3 | Q06418 | 7/20 | 0.52 |
| ▸ | MERTK | Q12866 | 7/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.48 |
| ▸ | BTK | Q06187 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | PLK1 | P53350 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | CDK4 | P11802 | 1/20 | 0.42 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22999829 | 0.88 | CDK5 (0.51) | LMNATP53CDK5CDK5R1CDK2 | |
| SCHEMBL9959330 | 0.88 | CDK5 (0.71) | CDK5CDK5R1CDK2CCNA2AXL | |
| SCHEMBL9959983 | 0.88 | CDK5 (0.69) | LMNACDK5CDK5R1CDK2CCNA2 | |
| SCHEMBL17620613 | 0.85 | PDGFRB (0.58) | PDGFRBBRD4 | |
| SCHEMBL22999621 | 0.83 | CDK5 (0.51) | CDK5CDK5R1CDK2CCNA2AXL | |
| SCHEMBL22999525 | 0.81 | MAPT (0.47) | LMNATP53CDK5CDK5R1CDK2 | |
| SCHEMBL23021031 | 0.81 | LMNA (0.53) | LMNATP53CDK5CDK5R1CDK2 | |
| SCHEMBL23021288 | 0.81 | PLK1 (0.47) | LMNATP53CDK5CDK5R1CDK2 | |
| SCHEMBL9959736 | 0.80 | MAPT (0.55) | CDK5CDK5R1CDK2CCNA2MAPT | |
| Hydrochloric Acid SCHEMBL22999798 | 0.80 | PLK1 (0.46) | LMNATP53CDK5CDK5R1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012085167-A1 | METABOTROPIC GLUTAMATE RECEPTOR MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2012-06-28 | — | — | WO | claimed |
| WO-2012085167-A1 | METABOTROPIC GLUTAMATE RECEPTOR MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2012-06-28 | — | — | WO | disclosed |