Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 11/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.47 |
| ▸ | P4HA1 | P13674 | 2/20 | 0.44 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.44 |
| ▸ | RARB | P10826 | 1/20 | 0.43 |
| ▸ | MIF | P14174 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.43 |
| ▸ | GABRP | O00591 | 1/20 | 0.42 |
| ▸ | GABRD | O14764 | 1/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.42 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.42 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.42 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.42 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.42 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.42 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.42 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18823613 | 0.80 | HCAR3 (0.50) | HCAR3MAPTHCAR2RARBTP53 | |
| SCHEMBL9951187 | 0.79 | HCAR3 (0.51) | HCAR3MAPTHCAR2P4HA1P4HTM | |
| SCHEMBL9960380 | 0.77 | HCAR3 (0.47) | HCAR3MAPTHCAR2P4HA1P4HTM | |
| SCHEMBL10095114 | 0.77 | HCAR3 (0.55) | HCAR3MAPTHCAR2P4HA1P4HTM | |
| SCHEMBL30827553 | 0.76 | P4HA1 (0.57) | HCAR3MAPTHCAR2P4HA1P4HTM | |
| SCHEMBL25754457 | 0.76 | HCAR3 (0.58) | HCAR3MAPTHCAR2P4HA1P4HTM | |
| SCHEMBL20425879 | 0.75 | RARB (0.50) | MAPTRARBTP53TSHRPLA2G4B | |
| SCHEMBL30043919 | 0.74 | HCAR3 (0.56) | HCAR3MAPTHCAR2P4HA1P4HTM | |
| Terephthalic Acid SCHEMBL29199831 | 0.74 | RARB (0.53) | MAPTRARBTP53TSHRPLA2G4B | |
| SCHEMBL100969 | 0.74 | HCAR3 (0.56) | HCAR3MAPTHCAR2P4HA1P4HTM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655331-A1 | GLUCAGON RECEPTOR MODULATORS | Pfizer Inc (US) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012085745-A1 | GLUCAGON RECEPTOR MODULATORS | PFIZER INC. (US) | 2012-06-28 | — | — | WO | disclosed |