Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 2/20 | 0.37 |
| ▸ | MMP1 | P03956 | 1/20 | 0.37 |
| ▸ | MMP3 | P08254 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 5/20 | 0.37 |
| ▸ | RAB9A | P51151 | 5/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 7/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | RELA | Q04206 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | MMP13 | P45452 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL995981 | 0.86 | ADAM17 (0.43) | ADAM17MMP3NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL995531 | 0.81 | ADAM17 (0.37) | ADAM17MMP1MMP3L3MBTL1EPHX2 | |
| SCHEMBL995534 | 0.81 | ADAM17 (0.37) | ADAM17MMP1MMP3L3MBTL1EPHX2 | |
| SCHEMBL16054126 | 0.80 | NPC1 (0.41) | NPC1RAB9ASMN1; SMN2LMNAACHE | |
| SCHEMBL16054821 | 0.80 | SMN1; SMN2 (0.41) | NPC1RAB9ASMN1; SMN2LMNAACHE | |
| SCHEMBL16054686 | 0.79 | SIGMAR1 (0.43) | NPC1RAB9ASMN1; SMN2LMNAACHE | |
| SCHEMBL1000040 | 0.78 | SMN1; SMN2 (0.50) | NPC1RAB9ASMN1; SMN2LMNAACHE | |
| SCHEMBL996324 | 0.78 | EPHX2 (0.35) | NPC1RAB9ASMN1; SMN2LMNAACHE | |
| SCHEMBL996323 | 0.74 | EPHX2 (0.34) | NPC1RAB9ASMN1; SMN2HPGDL3MBTL1 | |
| SCHEMBL995533 | 0.72 | GAA (0.38) | SMN1; SMN2LMNAMAPTKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2448920-A1 | NOVEL BENZENESULFONAMIDE COMPOUNDS, METHOD FOR SYNTHESIZING SAME, AND USE THEREOF IN MEDICINE AS WELL AS IN COSMETICS | Galderma Research & Development (FR) | 2012-05-09 | — | — | EP | disclosed |
| WO-2011001089-A1 | NOVEL BENZENESULFONAMIDE COMPOUNDS, METHOD FOR SYNTHESIZING SAME, AND USE THEREOF IN MEDICINE AS WELL AS IN COSMETICS | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2011-01-06 | — | — | WO | disclosed |