Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 4/20 | 0.33 |
| ▸ | RAB9A | P51151 | 4/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | RELA | Q04206 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | HRH2 | P25021 | 1/20 | 0.31 |
| ▸ | HRH1 | P35367 | 1/20 | 0.31 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL995979 | 0.87 | TDP1 (0.41) | L3MBTL1NPSR1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL16054124 | 0.81 | KDM4E (0.39) | L3MBTL1POLBNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL16054933 | 0.79 | HRH2 (0.41) | L3MBTL1POLBNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1000039 | 0.78 | SMN1; SMN2 (0.49) | L3MBTL1POLBNPSR1NPC1RAB9A | |
| SCHEMBL16054685 | 0.78 | SIGMAR1 (0.38) | L3MBTL1NPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL996327 | 0.78 | ADAM17 (0.37) | EPHX2L3MBTL1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL996323 | 0.73 | EPHX2 (0.34) | EPHX2L3MBTL1POLBNPSR1NPC1 | |
| SCHEMBL995317 | 0.72 | ALDH1A1 (0.44) | NPC1RAB9AHPGDTP53KMT2A | |
| SCHEMBL25422646 | 0.71 | NPC1 (0.41) | EPHX2L3MBTL1POLBNPSR1NPC1 | |
| SCHEMBL996067 | 0.71 | MAPK1 (0.49) | POLBNPC1RAB9ASMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2448920-A1 | NOVEL BENZENESULFONAMIDE COMPOUNDS, METHOD FOR SYNTHESIZING SAME, AND USE THEREOF IN MEDICINE AS WELL AS IN COSMETICS | Galderma Research & Development (FR) | 2012-05-09 | — | — | EP | disclosed |
| WO-2011001089-A1 | NOVEL BENZENESULFONAMIDE COMPOUNDS, METHOD FOR SYNTHESIZING SAME, AND USE THEREOF IN MEDICINE AS WELL AS IN COSMETICS | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2011-01-06 | — | — | WO | disclosed |