Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 11/20 | 0.89 |
| ▸ | NPC1 | O15118 | 10/20 | 0.89 |
| ▸ | MEN1 | O00255 | 2/20 | 0.89 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.89 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.72 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.72 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.72 |
| ▸ | AURKA | O14965 | 1/20 | 0.72 |
| ▸ | PIK3C2G | O75747 | 1/20 | 0.72 |
| ▸ | CDK1 | P06493 | 1/20 | 0.72 |
| ▸ | CDK4 | P11802 | 1/20 | 0.72 |
| ▸ | CCND1 | P24385 | 1/20 | 0.72 |
| ▸ | CDK2 | P24941 | 1/20 | 0.72 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.72 |
| ▸ | CCND3 | P30281 | 1/20 | 0.72 |
| ▸ | MAPK4 | P31152 | 1/20 | 0.72 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.72 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.72 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.72 |
| ▸ | CDK8 | P49336 | 1/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7335284 | 0.90 | RAB9A (0.74) | RAB9ANPC1MEN1KMT2AMAPK1 | |
| Hydrochloric Acid SCHEMBL4079710 | 0.87 | RAB9A (0.69) | RAB9ANPC1MEN1KMT2AMAPK1 | |
| SCHEMBL30405852 | 0.85 | MAPK1 (1.00) | RAB9ANPC1MEN1KMT2AMAPK1 | |
| SCHEMBL7335296 | 0.85 | RAB9A (0.66) | RAB9ANPC1MEN1KMT2AMAPK1 | |
| SCHEMBL4297399 | 0.83 | RAB9A (0.64) | RAB9ANPC1MEN1KMT2AMAPK1 | |
| SCHEMBL1119373 | 0.83 | RAB9A (0.71) | RAB9ANPC1MEN1KMT2AMAPK1 | |
| SCHEMBL2956673 | 0.83 | RAB9A (0.71) | RAB9ANPC1MEN1KMT2AMAPK1 | |
| SCHEMBL5413640 | 0.82 | RAB9A (0.63) | RAB9ANPC1MEN1KMT2AMAPK1 | |
| SCHEMBL4290771 | 0.82 | NPC1 (0.79) | RAB9ANPC1MEN1KMT2AHSD17B10 | |
| SCHEMBL3892750 | 0.81 | RAB9A (0.68) | RAB9ANPC1MEN1KMT2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8202889-B2 | Inhibitors of bacterial IMPDH | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-06-19 | — | — | US | disclosed |
| US-8202889-B2 | Inhibitors of bacterial IMPDH | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-06-19 | — | — | US | disclosed |
| US-20070191434-A1 | Inhibitors of bacterial IMPDH | VERTEX PHARMACEUTICALS INCORPORATED | 2007-08-16 | — | — | US | disclosed |
| US-20070191434-A1 | Inhibitors of bacterial IMPDH | VERTEX PHARMACEUTICALS INCORPORATED | 2007-08-16 | — | — | US | disclosed |
| WO-2007030617-A1 | INHIBITORS OF BACTERIAL IMPDH | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-03-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070191434-A1 | Inhibitors of bacterial IMPDH | IMPDH1, IMPDH2, IMPA1 | RAB9A 1725/4885NPC1 452/4885MEN1 2961/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.