Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM33 | Q9BZ11 | 8/20 | 0.69 |
| ▸ | ADAM17 | P78536 | 6/20 | 0.56 |
| ▸ | MMP2 | P08253 | 6/20 | 0.53 |
| ▸ | MMP13 | P45452 | 5/20 | 0.53 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.53 |
| ▸ | MMP14 | P50281 | 1/20 | 0.53 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.53 |
| ▸ | MMP3 | P08254 | 6/20 | 0.51 |
| ▸ | MMP1 | P03956 | 3/20 | 0.51 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.49 |
| ▸ | MMP8 | P22894 | 2/20 | 0.49 |
| ▸ | MMP9 | P14780 | 3/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL996437 | 1.00 | ADAM33 (0.69) | ADAM33ADAM17MMP2MMP13ADAMTS4 | |
| SCHEMBL997831 | 0.90 | ADAM33 (0.57) | ADAM33ADAM17MMP2MMP13ADAMTS4 | |
| SCHEMBL997830 | 0.90 | ADAM33 (0.57) | ADAM33ADAM17MMP2MMP13ADAMTS4 | |
| SCHEMBL998050 | 0.90 | ADAM17 (0.71) | ADAM33ADAM17MMP2MMP13ADAMTS4 | |
| SCHEMBL998048 | 0.90 | ADAM17 (0.71) | ADAM33ADAM17MMP2MMP13ADAMTS4 | |
| SCHEMBL2680436 | 0.90 | ADAM33 (0.57) | ADAM33ADAM17MMP2MMP13ADAMTS4 | |
| SCHEMBL996444 | 0.82 | ADAM33 (1.00) | ADAM33ADAM17MMP3MMP1 | |
| SCHEMBL996447 | 0.82 | ADAM33 (1.00) | ADAM33ADAM17MMP3MMP1 | |
| SCHEMBL2682839 | 0.81 | ADAM17 (0.80) | ADAM33ADAM17MMP3MMP1ADAM10 | |
| SCHEMBL2682836 | 0.81 | ADAM17 (0.80) | ADAM33ADAM17MMP3MMP1ADAM10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2448931-B1 | Benzenesulfonamide compounds, method for synthesizing same, and use thereof in medicine | GALDERMA RES & DEV (FR) | 2015-05-27 | — | — | EP | claimed |
| EP-2448931-B1 | Benzenesulfonamide compounds, method for synthesizing same, and use thereof in medicine | GALDERMA RES & DEV (FR) | 2015-05-27 | — | — | EP | disclosed |
| EP-2448931-A1 | NOVEL BENZENESULFONAMIDE COMPOUNDS, METHOD FOR SYNTHESIZING SAME, AND USE THEREOF IN MEDICINE AS WELL AS IN COSMETICS | Galderma Research & Development (FR) | 2012-05-09 | — | — | EP | disclosed |
| WO-2011001088-A1 | NOVEL BENZENESULFONAMIDE COMPOUNDS, METHOD FOR SYNTHESIZING SAME, AND USE THEREOF IN MEDICINE AS WELL AS IN COSMETICS | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2011-01-06 | — | — | WO | disclosed |