Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM33 | Q9BZ11 | 7/20 | 0.57 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.49 |
| ▸ | MMP2 | P08253 | 1/20 | 0.49 |
| ▸ | MMP13 | P45452 | 1/20 | 0.49 |
| ▸ | MMP14 | P50281 | 1/20 | 0.49 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.47 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.46 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | NPY1R | P25929 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL997830 | 1.00 | ADAM33 (0.57) | ADAM33ADAMTS4MMP2MMP13MMP14 | |
| SCHEMBL2680436 | 0.91 | ADAM33 (0.57) | ADAM33ADAMTS4MMP2MMP13MMP14 | |
| SCHEMBL996437 | 0.90 | ADAM33 (0.69) | ADAM33ADAMTS4MMP2MMP13MMP14 | |
| SCHEMBL996438 | 0.90 | ADAM33 (0.69) | ADAM33ADAMTS4MMP2MMP13MMP14 | |
| SCHEMBL997159 | 0.89 | ADAM17 (0.60) | ADAM33ADAMTS4MMP2MMP13MMP14 | |
| SCHEMBL997161 | 0.89 | ADAM17 (0.60) | ADAM33ADAMTS4MMP2MMP13MMP14 | |
| SCHEMBL27853846 | 0.81 | ADAM17 (0.59) | ADAM33ADAMTS4MMP2MMP13MMP14 | |
| SCHEMBL998048 | 0.80 | ADAM17 (0.71) | ADAM33ADAMTS4MMP2MMP13MMP14 | |
| SCHEMBL998050 | 0.80 | ADAM17 (0.71) | ADAM33ADAMTS4MMP2MMP13MMP14 | |
| SCHEMBL998393 | 0.79 | ADAM33 (0.83) | ADAM33ADAMTS4MMP2MMP13MMP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2448931-B1 | Benzenesulfonamide compounds, method for synthesizing same, and use thereof in medicine | GALDERMA RES & DEV (FR) | 2015-05-27 | — | — | EP | disclosed |
| EP-2448931-A1 | NOVEL BENZENESULFONAMIDE COMPOUNDS, METHOD FOR SYNTHESIZING SAME, AND USE THEREOF IN MEDICINE AS WELL AS IN COSMETICS | Galderma Research & Development (FR) | 2012-05-09 | — | — | EP | disclosed |
| WO-2011001088-A1 | NOVEL BENZENESULFONAMIDE COMPOUNDS, METHOD FOR SYNTHESIZING SAME, AND USE THEREOF IN MEDICINE AS WELL AS IN COSMETICS | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2011-01-06 | — | — | WO | disclosed |