Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 11/20 | 0.33 |
| ▸ | PDCD1 | Q15116 | 5/20 | 0.33 |
| ▸ | CD274 | Q9NZQ7 | 5/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.31 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.31 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.31 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.31 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9964449 | 0.89 | FFAR1 (0.34) | FFAR1PDCD1CD274 | |
| SCHEMBL9964431 | 0.88 | MCHR1 (0.34) | FFAR1PDCD1CD274 | |
| SCHEMBL9964438 | 0.88 | CD274 (0.38) | ESR1FFAR1PDCD1CD274 | |
| SCHEMBL9934745 | 0.86 | FFAR1 (0.43) | FFAR1 | |
| SCHEMBL9964436 | 0.86 | FFAR1 (0.36) | FFAR1PDCD1CD274 | |
| SCHEMBL9964424 | 0.83 | CD274 (0.33) | FFAR1PDCD1CD274 | |
| SCHEMBL12632545 | 0.81 | CD274 (0.38) | FFAR1PDCD1CD274 | |
| SCHEMBL15485585 | 0.81 | FFAR1 (0.33) | FFAR1PDCD1CD274 | |
| SCHEMBL9964421 | 0.80 | PDCD1 (0.43) | PDCD1CD274 | |
| SCHEMBL9964360 | 0.79 | CD274 (0.33) | FFAR1PDCD1CD274 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8476287-B2 | 3-hydroxy-5-arylisothiazole derivative | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2013-07-02 | — | — | US | disclosed |
| US-8476287-B2 | 3-hydroxy-5-arylisothiazole derivative | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2013-07-02 | — | — | US | disclosed |
| US-20120157459-A1 | NOVEL 3-HYDROXY-5-ARYLISOTHIAZOLE DERIVATIVE | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2012-06-21 | — | — | US | disclosed |
| US-20120157459-A1 | NOVEL 3-HYDROXY-5-ARYLISOTHIAZOLE DERIVATIVE | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2012-06-21 | — | — | US | disclosed |
| WO-2011078371-A1 | NOVEL 3-HYDROXY-5-ARYLISOTHIAZOLE DERIVATIVE | 持田製薬株式会社 (JP) | 2011-06-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120157459-A1 | NOVEL 3-HYDROXY-5-ARYLISOTHIAZOLE DERIVATIVE | GPR119, GPR27, NR0B1 | ESR1 274/4885FFAR1 39/4885PDCD1 4644/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.